Nanotechnology and Public Policy

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Center for Biological and Environmental
Nanotechnology
Science and Engineering at the Wet/Dry Interface
Dr. Vicki Colvin colvin_at_rice.edu
NSF NanoGrantees Program Year 8 December 7,
2009
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Our Centers Accomplishments
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CBENs Future Children of CBEN

• Intellectual focal points have changed
• Multi-institutional partnerships much easier,
  better accepted
• Ideal RFP for CBEN children focused
  supercenters that integrate our programs with
  partners across nation and world

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CBEN The Basic Data
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The Mission of CBEN
Our mission is to create sustainable
nanotechnologies that improve human health and
the environment.

1. Motivation for CBEN
2. CBENs Strategy Year 8 and Beyond
3. Operations and Highlights

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Critical Social Needs Drive Innovation
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Nanomaterials Solve Problems
BiMetallic Catalysts
Nanogold on silica
Removing TCE in water
Shrinking Tumors
Water purification
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CBENs Organizing Principle
Nanoscience and Technology at the Wet/Dry
Interface
Functional Nanoparticle
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Engineering Wish-List for Nanoparticles
Common themes in both engineering areas

• High surface areas
• Catalytically active
• Tunable magnetic properties
• Responsive surface coatings
• Thermally stable
• Nontoxic and low impact
• Scalable manufacturing

• Near-infrared properties
• Non-fouling
• Targeted to cell types
• Biologically accessible
• Biocompatible
• Water soluble (buffers)
• Highly pure materials

Applications and implications need research
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B. CBENs Goal Where we want to go

• Long-range technology goals drive all center
  projects
• All efforts involve engineered nanoparticles in
  water
• Three theme areas Basic science, bio and
  envi-engineering

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The How Over the Center Lifespan
1 2 3 4 5 6 7 8 9 10
Year
Start-up
Develop
Spin-out
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CBENs Principles for Project Selection
Project A
Collaborations
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Three Plane Chart Organization for CBEN
NSF-mandated structure Engineering goals as
drivers Narrows CBEN focus
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CBEN Management Structure

• External advisory board
• Day to day operational staff
• Resource allocation by IRB

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CBENs Lifespan Middle Age
1 2 3 4 5 6 7 8 9 10
Year
Start-up
Develop
Spin-out

• Find special opportunities and niche for center
• Narrow focus on 2 3 key technology outcomes
• Begin to identify roadblocks for technology
  outcomes

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CBENs Niche Defined

• Inorganic components
• Near IR biophotonics
• Imaging and therapeutics

• Nanoparticle Implications
• Water purification
• Complex material designs

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CBEN History Narrowed Focus in 2005-6

• CBEN after renewal has a narrower focus
  provides for
• Resources for larger scale testing, systems level
  work
• Response to new hires in BIOE, Chemistry
• Natural integration of impact effort with
  applications
• Ongoing feedback from site visitors and advisory
  boards

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CBENs Strategic Plan Applications
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Addressing a Potential Roadblock

• Build a community beyond CBEN to meet this need
• High quality and neutral technical data
• Welcome all stakeholders to participate in
  process
• Knowledge transfer to government, industry,
  public

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Three Plane Diagram for Implications
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CBENs Lifespan Towards Sunset
1 2 3 4 5 6 7 8 9 10
Year
Start-up
Develop
Spin-out

• Build an international community around CBEN
  themes
• Focus center resources on primary technology
  outcomes
• Find partners for testbeds and commercialization
• Define new organizations to carry on mission
  after sunset

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SEEDS Less emphasis towards sunset

• CBEN seed funding has had good success
• Arsenic/magnetite project was a 2004 seed
• Combined imaging/therapy was a 2003 seed
• Bondos protein fiber work was a 2005 seed (move
  to AM)

• Towards sunset engage younger faculty
  strategically
• Develop single particle methods for nanobiology
  problems
• Link, Diehl, Suh add to expertise of Pasquali and
  Hafner
• Leverage expertise in nanoscale carbon and
  environment
• Masiello to study carbon sequestration and
  analysis
• Integrate fundamental biology more directly
• McNew included in nano-cell uptake and
  interactions

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Community-building Activities

• Expand available resources in areas central for
  CBEN mission
• Develop technical community beyond CBEN in key
  areas
• Catalyze projects and partnerships that utilize
  CBEN outcomes

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Developing Nano-Environmental Technology
Ref NIST GCR 02-841 (2002)
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Guanajuato Testbed

• Old mining town north of
• Mexico City, pop. 80,000
• Two Projects
• As removal using sand-nanomagnetite in-line
  filtration
• Wastewater photodisinfection with derivatized
  fullerenes

Target levels As 0.2 mg/l (UN) Coliforms 2,000
MPN/100ml (for irrigation)
UV disinfection of plant effluent
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Developing Biotechnology Roadblocks
First lab demo of near-IR heating
Nanospectra Biosciences
Human Trials Soon
GMP Issues
Biocompatibility
First publication
1999 2001 2003 2005 2007

• FDA approval is a major hurdle for CBENs systems
  goals
• General manufacturing principles (reproducibility
  and purity)
• Biocompatibility, clearance, distribution and
  excretion

Fundamental science is essential to rapid
commercialization
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3. CBENs Activities
To create sustainable nanotechnologies that
improve human health and the environment

• We do this by
• Exploring the wet/dry interface.
• Solving biomedical environmental problems.
• Nurturing sustainable nanotechnologies.
• Training future nanotechnologists.

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CBEN Calendar
2008-9 Year Begins (Y06)
2008 EAB Meeting
Theme strategy meetings
ICON/CBEN Meeting
Annual Report
CBEN Site Visit
Reverse Site Visit
NanoECOWorkshop
June
July
Sept
Nov
Jan
Mar
Aug
Oct
Dec
Feb
Apr
May
2009
2008

• EAB Useful early warning system and feedback
• 2009 Nano-Environmental Workshop
• CBEN/ICON Industrial Advisory Board Meeting

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CBENs Budget History
CBEN Supplement Funding Requested

• A temporary 1 reduction in 2006-7 for all NSF
  centers
• Loss of support from NSF-GEO directorate
  (118,000)
• Reduction in institutional cost-share to minimal
  level

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CBEN NCN Partnership
Quantitative Data on Nanoparticle Uptake and
Distribution

Purdue NCN computational scientists and HUB
environment
Models for NP Fate
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CBENs Budget Breakdown

• REU funding not included here (50,000 grant)
• Knowledge transfer commercialization, center
  travel
• Allocations among activities are constant Y08
  Y09

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CBEN Educational Outreach
Educational Outreach

• Strength of CBEN (2007, 2008)
• Focus on ALL of pipeline
• Extremely well leveraged programs

Inquiry Learning
Scalable Teacher Training
CBEN research inspired
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Educational Programs Effective Leveraged
Using nanotechnology as a meansnot an endto
science education

• We have reached thousands of students, teachers
  and citizens since 2005
• REU program awarded for community college
  outreach activity
• Project GRAD funding from local businesses
• HISD continues to be active partner and
  collaborator in our activities

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Connections to the Broader Community
Knowledge transfer industry interactions

• Innovative approach to KT challenge
• Reconceived industrial affiliates
• Community Building Activities

Eco-Responsible Design and Disposal of ENMs
ICON GoodNanoGuide
Backgrounders on Nano-EHS Papers
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A Reconception of Knowledge Transfer
CBEN nurtures sustainable commercialization by
engaging many stakeholders.
Media
Smaller Companies
CBEN
Government
Non-profits
Advocates
Academics
Large Industry
Standards Organizations
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CBENs Research Highlights
CBENs Research

• International leaders (SV07)
• Over 325 publications
• High impact, widely cited work

Nanomaterials for Bioengineering (Theme 2)
Nanoparticles and Environmental Engineering
(Theme 3)
Wet/dry Nanoscience (Theme 1)
Dr. Jennifer West Dr. Vicki Colvin Dr. Pedro
Alvarez Dr. Rebekah Drezek Dr. Jason Hafner
Shared theme leadership remaining two years
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CBENs Budget Research Breakdown
Year 8 Research funding by theme
Year 9 Research funding by theme

• Theme areas funded at comparable levels all years
• CBEN projects difficult to classify in a single
  theme
• Approximate funding per faculty per project is
  40,000

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Strong Interactions Between Themes
Theme 2
Theme 3
Theme 2
Theme 3
Biocompatibility
Biocompatibility
Nanotech Envi. Eng.
NanoTech for Bio. Eng.
Nanobioconjugates
for
Nanoparticles in the


Bioengineering
Environment
Surface Fouling
surface fouling
Nanomanufacturing


Nanoparticle Toxicity
Nanoparticle toxicity
Lower environmental
Lower environmental


impact
impact
Optical Properties
optical properties
Provide
Provide
Optimize Create
Optimize create
nanomaterials and
nanomaterials and
Theme 1
Novel Nanomaterials
novel nanomaterials
design principles
design principles
Theme 1
Wet/Dry Nanoscience
Fundamentals of
Nanoparticles in Water
Shared needs and enabling technologies provide
added value for CBEN
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CBEN Research Highlights
gt 300 invited center presentations gt 350
accepted publications
Natural organic matter association with carbon
Schematic of iron oxide-lipid bilayer complex
Nanoscale imaging materials for environmental
species

• Lipid bilayers formed around rigid and small
  diameter (d lt 20 nm) particles (Nanoscience at
  the wet/dry interface)
• Gold-based nanoparticles used in new clinical
  applications (glioma) for photothermal therapy
  (Nanomaterials for bioengineering)
• Degradation of quantum dots and their coatings by
  common microbes (Nanomaterials in the environment)

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CBEN Center Overview
Our mission is to create sustainable
nanotechnologies that improve human health and
the environment.

• Motivation for CBEN
• CBENs Strategy
• Highlights of Activities

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Agenda for 2009 CBEN Site Visit

• 730 am Site visitors meet in the lobby of the
  Hilton for transport to Rice University
• 745 815 am Continental Breakfast (Space
  Science Building, Rm. 337)
• 815 830 am Institutional Welcome, Dr. Wade
  Adams, Smalley Institute Director
• 830 850 am Director's Overview, Professor V.
  Colvin, CBEN Director
• 850 920 am Theme 2 Nanoparticles in
  Bioengineering Professor R. Drezek
• 920 950 am Theme 3 Nanomaterials in the
  Environment, Professor P. Alvarez
• 950 1010 am Break
• 1010 1040am Theme 1 Nanoscience at the
  Wet/Dry Interface Professor J. Hafner
• 1040 1110am Knowledge Outreach and Societal
  ImpactDr. K. Kulinowski
• 1110 1245pm BRC Building Tour and Poster
  Session with Graduate Students BioScience
  Research Collaborative (BRC) Building
• Box lunch to be served on 3rd floor, Rm. 300
• 100 pm Shuttle visitors back to main campus
• 100 130 Educational Outreach and Diversity
  Plan Professor J. Hutchinson
• 130 145 Strategic Plan and
  Institutionalization of Programs Professor V.
  Colvin
• 145 200 Institutional Directions and CBENs
  Legacy, Dean Daniel D. Carson
• 200 Site Visit Concludes