Actinomyces

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Actinomyces Nocardia
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Actinomyces

• A.israelii, A.naeslundii
• Gram positive sulfur granule
• Related to decay tooth and peridentitis

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ACTINOMYCES

• Anaerobic, filamentous, gram positive bacillus
• Exhibit true branching
• Mykes Greek for fungus
• Thought by early microbiologist to be fungi
  because of
• Morphology
• Disease they cause

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Clinical specimensActinomycosis-pus
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ACTINOMYCOSIS

• Not highly virulent (Opportunist)
• Component of Oral Flora
• Periodontal pockets
• Dental plaque
• Tonsilar crypts
• Take advantage of injury to penetrate mucosal
  barriers
• Coincident infection
• Trauma
• Surgery

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Actinomycosis

• A chronic suppurative and granulomatous???disease
  of the cervico-facial, thoracic or abdominal areas

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ACTINOMYCOSIS

• Form indurated masses with fibrous walls and
  central loculations with pus
• Pus contains "Sulfur Granules"
• Gritty, yellow white
• Average diameter - 2mm
• Composed of mineralized mycelial mass
•  
• Chronic infection
• Form burrowing sinus tracts to skin or mucus
  membranes
• Discharge purulent material

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Actinomycosis - sulfur granule
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Pulmonary Actinomycosis

• 15 of cases
• Aspiration of organism from the oropaharynx
• Slowly progressive process involving lung and
  pleura
• May be mistaken for malignancy
• Chest pain, fever, wgt loss and hemoptysis

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Mycetoma(???)

• Streptomyces species?

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Nocardiosis

• Subcutaneous infections, pulmonary infections,
  and brain abscesses
• N. asteroides N. brasiliensis

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Lab. Diagnosis

• Clinical SpecimensSputum,Pus,Biopsy tissue

Sulfamethoxazole-Trimethoprim