Fructose Intolerance

1
Fructose Intolerance
Glycogen
Fructose

• Lack of Pi
• Allosteric Inhibition by F-1-P

ATP
Glucose-6-P
Glucose
ADP
Fructose-1-P
1o Deficiency F-1-P Aldolase
F-1,6-BP

• Effects
• F-1-P
• Pi
• Glycogenolysis
• Gluconeogenesis
• Blood Glucose
• Reducing sugar ( ) in urine

DHAP Glyceraldehyde
DHAP G-3-P
Pyruvate

• Treatment
• Limit Fructose/Sucrose

2
Myocardial Infarction
Glycogen

• 1o Problem- Lack of O2
• Block of aerobic metabolism (ETS)
• Induction of anaerobic metabolism (Glycolysis)
• Effects
• ATP
• Creatine Phosphate
• Glycogen
• LDH
• Lactate/Pyruvate
• NADH/NAD

GLYCOLYSIS
Lactate Dehydrogenase (LDH)
Glucose
NADH
Pyruvate
Lactate
NAD
Acetyl CoA
TCA CYCLE
ETS
O2
NADH FADH2
ATP H2O
ADP Pi
CO2
3
Alcohol Abuse
Ethanol
Acetaldehyde
Acetate
NAD
NADH
NADH
NAD
NADH/NAD

• Effects
• NAD requiring reactions/ NADH forming reactions
• Lactate/Pyruvate
• Gluconeogenesis
• Fatty Acid Oxidation
• Glycerol-3-P
• Blood Glucose

• NAD to NADH Reactions
• G-3-P to 1,3 BPG (Glycolysis)
• Lactate to Pyruvate (Glycolysis)
• Glycerol-3-P to DHAP (Branch of Glycolysis)
• Many others

4
Glycogen Storage Disease (Type 1)Von Gierkes
Disease
Glucose-6-P Phosphatase
Glycogen
Glucose-6-P
Glucose
Pi

• Effects
• Glycogen
• Blood Glucose
• Free fatty acids
• Triglycerides
• Cholesterol
• Uric Acid
• Lactate

• Low Glucose
• Glucagon
• Phosphorylase Activity
• Glycogen to Glucose-6-P

5
Glucose-6-P Dehydrogenase
Glucose-6-P Dehydrogenase
6-Phosphogluconate DH
CO2
Glucose-6-P
6-P-Gluconate
Ribulose-5-P
NADPH
NADPH
NADP
NADP
NADPH/NADP

• Effects
• NADPH levels
• Reducing Power
• GSH/GS-SG
• Free radical/Peroxides
• Hemoglogin
• Hemolytic Anemia
• Lens