National Center for Research Resources NCRR

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National Center for Research Resources(NCRR)

• Barbara Alving, M.D.
• Acting Director
• National Center for Research Resources

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NCRR Translating Basic Discoveries into Improved
Patient Care
Clinical Research
Research Infrastructure
NCRR
Bench
Bedside
Biomedical Technology
Comparative Medicine
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NCRR Translating Basic Discoveries into Improved
Patient Care
Clinical Research
Research Infrastructure
NCRR
Bench
Bedside
Biomedical Technology
1.1 Billion
Comparative Medicine
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Research InfrastructureSidney McNairy, Ph.D.

• Funds development programs to
• enhance the competitiveness of
• investigators in underserved states
• and institutions.
• Provides funding to expand, remodel, and renovate
  or alter existing research facilities or
  construct new research facilities.

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Clinical Research ResourcesAnthony Hayward,
M.D., Ph.D.

• Provides clinical research environments
• and resources that enable studies of the
• full range of human disorders.
• Funds career-development programs
• that attract talented medical students,
• physicians, and dentists to the challenge
• of clinical research careers.
• Increases the public's understanding of medical
  research and delivers information about healthy
  living and career opportunities in science to
  children and the general public.

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Biomedical TechnologyMichael Marron, Ph.D.

• Stimulates basic research to
• develop versatile new technologies
• and methods that help researchers
• who are studying virtually every
• human disease.
• Provides access to state-of-the-art technologies
  and instruments that enable both basic biomedical
  research and clinical investigations of a
  multitude of health issues.

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Comparative MedicineFranziska Grieder, D.V.M.,
Ph.D.

• Trains veterinarians in translational
• research to enhance the countrys
• ability to respond to the emergence
• and spread of potentially deadly
• human diseases, such as SARS,
• influenza, and hepatitis.
• Develops and provides access to animal models,
  which offer essential clues to human disorders,
  such as AIDS, Parkinsons disease, and diabetes.

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Animal Model Resource Centers

• Non-human Primates
• National Primate Research Centers
• Chimpanzee Management
• Rodents
• Genetically engineered models
• Aquatics
• Zebrafish, sea slugs, squid, octopus
• Comparative Models
• drosophila, c. elegans, swine, stem cells

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Funding Clinical and Translational Science
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NIH Clinical and Translational Science Awards . .
. and Beyond

• Catalyze change - break silos, break barriers,
  and break conventions
• Advance the new intellectual discipline of
  clinical and translational science
• Integrate resources and training
• Identify and remove impediments to clinical and
  translational science

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NIH CTSA Awards A Home for Clinical and
Translational Science
NIH
Clinical Research Ethics
Trial Design
Advanced Degree-Granting Programs
Biomedical Informatics
CTSA HOME
Industry
Participant Community Involvement
Clinical Resources
Other Institutions
Biostatistics
Regulatory Support
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Integrating Clinical Research Networks

• Link existing networks so clinical studies and
  trials can be conducted more effectively
• Ensure that patients, physicians, and scientists
  form true Communities of Research
• National Electronic Clinical Trials and Research
  (NECTAR) Network

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Two Major Research and Education Backbone
Networks
Abilene and National Lambda Rail
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Biomedical Informatics Research Network (BIRN)
Enabling collaborative research at 28 research
institutions comprised of 37 research groups.
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IDeANETLariat Connecting universities and
researchers in the rural west to advanced
national cyberinfrastructure for access to
e-science opportunities and informatics
resources.
U. Alaska
Montana State U.
U. of Idaho
U. Wyoming
U. Nevada Reno
NMSU
U. Hawaii
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Connecting the dots. . . building network
infrastructure
IDeA States
IDeA RCMI
Challenges geography, economy, population density
Internet2 Institutions
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IDeA Highlights in Informatics

• University of New Mexico Health Sciences Center
  is a participating site in the Function BIRN
• North Dakota INBRE collaboration with University
  of Michigan NCRR-funded Center for Integrated
  Proteomics to provide research training
  opportunities in bioinformatics and proteomics
  applications

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Supporting underserved states and minority
institutions
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Building Capacity
INBRE- 23 statewide networks COBRE- 73 thematic
research centers RCMI- 18 sites including 5
clinical research centers IDeA RCMI sites
include 28 AHCs (7 GCRCs)
IDeA
RCMI
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NCRR Extramural Construction Alteration and
Renovation Programs

• Funds grants to public and nonprofit private
  entities to expand, remodel, renovate, alter or
  construct biomedical and behavioral research
  facilities.
• Achieves ultimate goal to build national
  biomedical research capacity to improve human
  health.

University of Puerto Rico
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Shared Instrumentation Grant (SIG) High-End
Instrumentation (HEI) Programs

• S10 mechanism is unique to NCRR
• Funding in cost-range from 100K to 2.0M
• Equipment that is too costly to obtain with
  regular NIH research grants
• Highly cost-effective
• Instruments placed in core facilities
• Shared by an average of 8-10 grantees

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IDeA States and SIG Awards
IDeA States (21 IDeA states have SIG Awards)
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Small Business Awards

• Small Business Innovation Research Awards (SBIR)
• Set-aside program for small business concerns to
  engage in federal R D with potential for
  commercialization.
• Small Business Technology Transfer Program (STTR)
• Set-aside program to facilitate cooperative RD
  between small business concerns and U.S. research
  institutions with potential for
  commercialization.

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IDeA States and NCRR SBIR/STTR Awards
IDeA States
NCRR SBIR and STTR Awards (5 IDeA states)
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Bringing medical research to the public
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Science Education Partnership Award (SEPA) Program

• Encourages and supports the interaction of
  scientists with educators and community
  organizations to improve K-12 and public
  understanding of NIH-funded medical research.
• Increases the participation of young people in
  science careers.
• Engages and educates the general public in
  medical research.

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Typical Lab
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Mobile Lab!
MDBioLab
City Lab, Boston University
UNC Chapel Hill Destiny Bus
Connecticut Bio Bus
Regional BioTech Bus, Texas
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IDeA States and SEPA
IDeA States
States with SEPA Awards (14/24)
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Providing training and career development
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Training and Career Development Programs

• New Investigator Programs
• Mid-Level Programs
• Re-Entry Programs

All complementary to the Mentor and Trainee
format of the IDeA Program
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Next Steps for IDeA States

• Leverage dollars and talent
• Nurture interdisciplinary research teams
• Develop partnerships and collaborations for
  funding and research
• Academic Health Centers
• NIH Institutes and Centers
• Other Federal Agencies
• Industry