Dynamic Contrast Enhanced T2 Perfusion MR Imaging

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Dynamic Contrast EnhancedT2 Perfusion MR Imaging

• Presented by Meng Li

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Introduction

• Fundamental Principle
• A bolus of contrast agent goes through a
  capillary
• network
• Transient changes in the MR signal
• MR signal time course
• concentration-time course (of tracer in
  tissue)
• tissue hemodynamic parameters (i.e.,
  CBF,CBV,MTT)

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Introduction

• Fig.1 DSC-MRI in a 4 year old child
• 12 hours after a stroke in the left
• basal and signal intensity time
• course plots
• ROI 1 right basal ganglia,
• ROI 2 left basal ganglia,
• ROI 3 peripheral branch of the right
• MCA
• Stroke region (ROI 2) shows almost
• no contrast agent passage.

ROI 1
ROI 2
ROI 3
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Introduction

• Quantification of Bolus Tracking Using Summary
  Parameters
• BAT bolus arrival time
• TTP time to peak
• MPC maximum peak concentration
• AUP area under the peak
• FWHM full width at half maximum