Section of a liver in low magnification

1
Section of a liver in low magnification
Portal triad
CV Central vein
CV
MZI Khan
2
Section of a liver
MZI Khan
Portal Triad

• This section of a liver
• is showing many
• hepatic lobules centered
• around central vein.
• Interlobular connective
• tissue is not present here,
• therefore, demarcation of
• lobules from one another is
• difficult here.

3
Section of a Pig Liver
MZI Khan

• Section of this liver is
• Showing
• Benzene-shaped
• hexagonal hepatic lobules,
• which are demarcated by
• connective tissue.
• Central vein at the center
• of lobule.
• Portal areas at the angle
• of lobules.

4
Section of Liver
MZI Khan

• Section showing central vein,
• sinusoids, and hepatic cords.
• Hepatic cords consisting of
• six sided liver cells (hepatocytes).
• The hepatocytes seems to be
• radiating from the central vein
• towards periphery of the hepatic
• lobule.
• Sinusoids are the open channel
• of blood in between the
• hepatocytes.

5
Section of a liver showing a lobule and surfaces
of the hepatocytes
MZI Khan

• Surfaces of hepatocytes
• (1)Microvillus surfaces that face the
• perisinusoidal space,
• (2) Surface that border the bile
• canaliculi, and
• (3) Contact surface between adjacent
• hepatocytes where apposed surface
• (lateral face).
• The hepatocytes have centrally located
• spherical nucleus with one or more
• prominent nucleoli. Occasionally
• binucleated cells may see

6
Portal areas/canal/triads of liver
MZI Khan

• Portal triads have
• Hepatic artery
• Portal vein, and
• Bile duct

7
Classification of hepatic lobules
MZI Khan
Classical hepatic lobule
Portal lobule
Liver acinus
8
Diagrammatic representation of Classical liver
lobule
MZI Khan
Composition of a lobule already discussed In the
previous slides.
9
The Portal Lobule of liver
Portal lobule is a functional unit centered
around the bile ductule in the portal area. It
is defined as a triangular area consisting of
the parenchyma of three adjacent hepatic lobules
that are drained by the bile ductule in the
portal canal.
10
Liver acinus
Liver acinus is a unit of parenchyma defined in
relation to its vascular supply. The liver
acinus is a roughly diamond shaped area made of
parts of two hepatic lobules supplied by terminal
branches of the interlobular portal vein and
hepatic artery. The blood vessels course at
right angles from the portal area between
two hepatic lobules to form backbone of
the acinus, and the two central veins are at the
two opposing points of the diamond. The liver
acinus is divided into three Zones zone1, 2, and
3.
11
Diagrammatic representation showing lining cell
of the sinusoids and space of Disse
MZI Khan

• Lining cells of the sinusoids are
• Porous endothelial cell
• Von Kupffer cell Macrophage,
• Perisinusoidal stellate cells or
• adipocyte, or Ito cell, which store
• vitamin A.

• Space of Disse is the space in between
• endothelium of the sinusoids and hepato
• -cytes. Here the exchange of the
• metabolites takes place.

12
Basic structure of Liver Lobule showing Flow of
Blood and Bile
MZI Khan
13
Basic Structure of Liver Lobule Showing Flow of
Blood and Bile
Flow of blood and bile in the hepatic Lobule is
opposite in direction
14
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