Features of the pathways of Ag processing

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Features of the pathways of Ag processing

• Feature Class II MHC Pathway Class I MHC
  Pathway
• Composition
• of MHC
• Types of APC
• Responsive T cell
• Source of Ags
• Enzymes responsible
• For peptide degradation
• Molecules involved in
• Transport of peptides and
• Loading of MHC molecules

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Features of the pathways of Ag processing

• Feature Class II MHC Pathway Class I MHC
  Pathway
• Composition alpha/beta chains alpha/beta 2-m
• of MHC
• Types of APC DC, MO, B cells
  (endothelial) All nucleated
• Responsive T cell CD4 T cells CD8 T cells
• Source of Ags Exogenous Endogenous
• Enzymes responsible Endosomal and
  lysosomal Cytosolic
• For peptide degradation proteases proteasome
• Molecules involved in
• Transport of peptides and Invariant chain (Ii),
  HLA-DM TAP
• Loading of MHC molecules

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Kuby Figure 8-8
Viral immune evasion