CHMI 2227E Biochemistry I

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CHMI 2227EBiochemistry I

• Enzymes
• Regulation

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Regulation of enzyme activity
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Regulation of enzyme activity1. Allostery
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Regulation of enzyme activity1. Allostery
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Regulation of enzyme activity1. Allostery -
ATCase
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Regulation of enzyme activity1. Allostery -
ATCase
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Regulation of enzyme activity2. Regulatory
subunits
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Regulation of enzyme activity3. Regulation by
covalent modification
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Regulation of enzyme activity3. Regulation by
phosphorylation
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Regulation of enzyme activity3. Phosphorylation
? Adrenaline
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Regulation of enzyme activity4. Regulation of
enzyme stability
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Regulation of enzyme activity4. Regulation of
enzyme stability
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Regulation of enzyme activity4. Regulation of
enzyme stability
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Regulation of enzyme activity5. Limited
proteolysis
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Regulation of enzyme activity5. Limited
proteolysis
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Regulation of enzyme activity5. Limited
proteolysis
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Regulation of enzyme activity5. Limited
proteolysis