MEDJADEN

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MEDJADEN BIOMEDICAL SERVICES ???????????
??????? ????????????????????????? ????? Editor-i
n-Chief, Medjaden
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More dedicationmore publicationProf. Colm A.
OMorainDublin University, Ireland
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It is amazing you write such excellent papers
Prof. Nicholas J. Talley, Editor-in-Chief, AJG
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Copy from one, it's plagiarism copy from many,
it's research. -Wilson Mizner (1876-1933)
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1988?-2009?????

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• ???? 23?
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• ???? 6

7
??? ???. ???????-?????. ?1?.?? ????????? 1997
(?????)1998 (?????)
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????????(?)????????? ???????
???????????

• ????????
• Xia HX, Daw MA, Beattie S, Keane CT, O'Morain CA.
  Prevalence of metronidazole-resistant
  Helicobacter pylori in dyspeptic patients. Ir J
  Med Sci 199316291-4.
• Xia HX, Buckley M, Keane CT, O'Morain CA. J
  Clarithromycin resistance in Helicobacter pylori
  prevalence in untreated dyspeptic patients and
  stability in vitro. Antimicrob Chemother
  199637473-81.
• ??????????????
• Xia HX, Windle HJ, Marshall DG, Smyth CJ, Keane
  CT, O'Morain CA. Recrudescence of Helicobacter
  pylori after apparently successful eradication
  novel application of randomly amplified
  polymorphic DNA fingerprinting. Gut 19953730-4.
  
• Xia HX, Gilvarry J, Beattie S, Hamilton H, Keane
  CT, Sweeney EC, O'Morain CA. Recrudescence of
  Helicobacter pylori infection in patients with
  healed duodenal ulcer after treatment with
  different regimens. Am J Gastroenterol
  1995901221-5.

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????????(?)?????????????????

• ??????????????
• Xia HX, Buckley M, Keane CT, OMorain CA.
  Clarithromycin resistance in Helicobacter pylori
  prevalence in untreated dyspeptic patients and
  stability in vitro. J Antimicrob Chemother 1996
  37 473-481.

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????????(?)??????????,????

• ?????????????
• Xia B, Xia HH, Ma CW, Wong KW, Fung FM, Hui CK,
  Chan CK, Chan AO, Lai KC, Yuen MF, Wong BC.
  Trends in the prevalence of peptic ulcer disease
  and Helicobacter pylori infection in family
  physician-referred uninvestigated dyspeptic
  patients in Hong Kong. Aliment Pharmacol Ther
  200522243-9.

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????????(?)???????? ???????

• ???????????????????
• Yang Y, Deng CS, Peng JZ, Wong BC, Lam SK, Xia
  HH. Effect of Helicobacter pylori on apoptosis
  and apoptosis related genes in gastric cancer
  cells. Mol Pathol ( J Clin Pathol) 20035619-24.

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????????(?)??????? ????????

• ????????????
• Xia HX, English L, Keane CT, O'Morain CA.
  Enhanced cultivation of Helicobacter pylori in
  liquid media. J Clin Pathol 199346 750-3.
• ?????????????
• Xia HX, Keane CT, O'Morain CA. Pre-formed urease
  activity of Helicobacter pylori as determined by
  a viable cell count technique--clinical
  implications. J Med Microbiol 199440435-9.

13
????????(?)???????? ????????

• ?????????????????????
• Xia HH, Talley NJ, Kam EP, Young LJ, Hammer J,
  Horowitz M. Helicobacter pylori infection is not
  associated with diabetes mellitus, nor with upper
  gastrointestinal symptoms in diabetes
  mellitus.Am J Gastroenterol (IF 6.444). 2001
  Apr96(4)1039-46.
• ??????????????????????????
• Jones KL, Wishart JM, Berry M, Russo A, Xia HH,
  Talley NJ, Horowitz M. Helicobacter pylori
  infection is not associated with delayed gastric
  emptying or upper gastrointestinal symptoms in
  diabetes mellitus.Dig Dis Sci 200247704-9.

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????????(?)?????????????,???????
??????Mapping??
????? ???????????????????????????????????????????
???????

• ???
• ????????????????
• Xia HH, Kalantar J, Talley NJ. Metronidazole- and
  clarithromycin-resistant Helicobacter pylori in
  dyspeptic patients in western Sydney as
  determined by testing multiple isolates from
  different gastric sites. J Gastroenterol Hepatol
  1998131044-9.
• ??????????????
• Can helicobacter pylori serology still be applied
  as a surrogate marker to identify peptic ulcer
  disease in dyspepsia? Xia HH, Kalantar JS,
  Mitchell HM, Talley NJ. Aliment Pharmacol Ther
  200014615-24.

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????????(?)?????????????,???????
???(Antralization)?????
A
?????
??????????

• Xia HH, Kalantar JS, Talley NJ, Wyatt JM, Adams
  S, Chueng K, Mitchell HM. Antral-type mucosa in
  the gastric incisura, body, and fundus
  (antralization) a link between Helicobacter
  pylori infection and intestinal metaplasia? Am J
  Gastroenterol 200095114-21.

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????????(?)?????????????? -????,????

• ??? (Antralization)?????
• Xia HH, Zhang GS, Talley NJ, Wong BC, Yang Y,
  Henwood C, Wyatt JM, Adams S, Cheung K, Xia B,
  Zhu YQ, Lam SK. Topographic association of
  gastric epithelial expression of Ki-67, Bax, and
  Bcl-2 with antralization in the gastric incisura,
  body, and fundus.Am J Gastroenterol.
  2002973023-31.
• Xia HH, Lam SK, Wong WM, Hu WH, Lai KC, Wong SH,
  Leung SY, Yuen ST, Wright NA, Wong BC.
  Antralization at the edge of proximal gastric
  ulcers does Helicobacter pylori infection play a
  role? World J Gastroenterol 200391265-9.
• Xia HH, Yang Y, Lam SK, Wong WM, Leung SY, Yuen
  ST, Elia G, Wright NA, Wong BC. Aberrant
  epithelial expression of trefoil family factor 2
  and mucin 6 in Helicobacter pylori infected
  gastric antrum, incisura, and body and its
  association with antralisation. J Clin Pathol
  200457861-6.
• Xia HH, Wong BC, Zhang GS, Yang Y, Wyatt JM,
  Adams S, Cheung K, Lam SK, Talley NJ.
  Antralization of gastric incisura is
  topographically associated with increased gastric
  epithelial apoptosis and proliferation, but not
  with CagA seropositivity. J Gastroenterol Hepatol
  2004191257-63.
• Zhu S, Xia HH, Yang Y, Ma J, Chen M, Hu P, Gu Q,
  Liang Y, Lin H, Wong BC. Alterations of gastric
  homeoprotein expression in Helicobacter pylori
  infection, incisural antralisation, and
  intestinal metaplasia. Dig Dis Sci
  200954996-1002.
• Ma J, Chen M, Wang J, Xia HH, Zhu S, Liang Y, Gu
  Q, Qiao L, Dai Y, Zou B, Li Z, Zhang Y, Lan H,
  Wong BC. Pancreatic duodenal homeobox-1 (PDX1)
  functions as a tumor suppressor in gastric
  cancer. Carcinogenesis 2008291327-33.

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????????(?) (Review 1)

• ????-??????????????????
• Xia HHX, Talley NJ. Natural acquisition and
  spontaneous elimination of Helicobacter pylori
  infection. Am J Gastroenterol 1997 92
  1780-1787.
• Xia HHX, Talley NJ, Keane CT, OMorain CA.
  Recurrence of Helicobacter pylori infection after
  successful eradication nature, possible causes
  and potential preventive strategies. Dig Dis Sci
  1997 42 1821-1834.

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????????(?)(Review 2)

• ???? - ??????????????????
• Xia HHX, Talley NJ. Helicobacter pylori
  infection, atrophic gastritis and reflux
  esophagitis an unexplored triangle. Am J
  Gastroenterol 1998 93 394-400.
• Xia HHX, Talley NJ. Apoptosis in gastric
  epithelium induced by Helicobacter pylori
  infection implications in gastric
  carcinogenesis. Am J Gastroenterol 2001 96
  16-26.

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????????(?)(Review 3)

• ???? - ??(????????)
• Xia HHX, Wong BCY, Talley NJ, Lam SK.
  Helicobacter pylori infection current treatment
  practice. Expert Opin Pharmacother 2001 2
  253-266.
• Xia HHX, Wong BCY, Talley NJ, Lam SK. Alternative
  and rescue treatment regimens for Helicobacter
  pylori eradication. Expert Opin Pharmacother
  2002 3 1301-1311.
• Xia HHX, Wong BCY. Gastric biopsy based rapid
  urease tests for the detection of Helicobacter
  pylori progress, advantages and limitations. J
  Gastroenterol Hepatol 2002 17629-32.

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??(Letter to editor)

• ??
• Correspondence letter??????????
• Warren JR, Marshall BJ. Unidentified curved
  bacilli on gastric epithelium in active chronic
  gastritis. Lancet 1983 1 127375.
• Letter to editor??????????
• Xia HX, Keane CT, O'Morain CA. Eradication rate
  of Helicobcter pylori. Gut 199537591-2.
• ????????????????????????
• Zheng MH, Xia HH, Chen YP. Rectal administration
  of NSAIDs in the prevention of post-ERCP
  pancreatitis a complementary meta-analysis. Gut
  2008 57 1632-3.

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Nobel Prize in Medicine in 2005
Barry J. Marshall and J. Robin Warren for their
discovery of the bacterium Helicobacter pylori
and its role in Gastritis and Peptic Ulcer
Disease
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Lancet 2005 3661429.
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??????????(???)

• ???????????(Academic misconduct or dishonesty)
• ?????Plagiarism The adoption or reproduction of
  ideas or words or statements of another person
  without due acknowledgment
• ?????Fabrication The falsification of data,
  information, or citation in any formal academic
  exercise
• ??Deception Providing false information to an
  instructor concerning a formal academic
  exercisee.g., giving a false excuse for missing
  a deadline or falsely claiming to have submitted
  work
• ??Cheating Any attempt to give or obtain
  assistance in a formal academic exercise (like an
  examination) without due acknowledgment.
• ????Sabotage Acting to prevent others from
  completing their work. This includes cutting
  pages out of library books or willfully
  disrupting the experiments of others
• (???)????Professorial misconduct Professorial
  acts that are academically fraudulent equate to
  academic fraud

http//en.wikipedia.org/wiki/Academic_misconduct
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?? Infect Immun Zhonghua Yi Xue Za Zhi
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? 2000 2003
?? ABC induces an XYZ-resistant phenotype. ABC induces XYZ-resistance in XXX cells
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2004?SCI??57,377?
2007?SCI??89,100?
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