Title: TK?IL-2?RAR
1 ????? ?????????????? immunotherapy and
genetherapy for Oral Cancer ??? ??
2- ????????
- ??????????????
- ????????????????(??)???????????,????????,????
- ???????????
3???? 1. ????????????????? 2.   Â
 ???? 3.      ????? 4.      ?????????? 5.     Â
???????? 6.      DNA?? 7.     Â
????,?????? 8.      ?????? 9.      ????
4??? ???????????Immunotherapy of Oral Cancer
5???????
-
- ???????????
- ?????????????
- ????????????
- ???????????????
- ????????????
6????????
- ??????
- ???????
- ?????????????????
- ????????????
- ?????????
- ??????????????
- ?????????
7??????????
- ??????
- ?????????????????????????
-
8??????????
?????? ?????????????????????????
9?????????
- ???????????
- ????,??????????
- ??????????????
- ?????????
10?????????
- ??????
- ????(T????????????????????)
- ????(?????)
- ????(IL-2?IFNs?TNFa?)
11(?)???
- ??????????????
- ?????????
- ??????????????????
-
12(?)???
- BCG????????
- ??????????
- ??????????????
- ??T?????????????
- ??T????????
13????
- ????
- ????????BCG(50-75mg/ml)
- ????????BCG(0.75mg/ml)
- ????
- ??????????
- ??????1mg/ml,????,?3?
-
14????
- ?????
- ??????????????????
- ????5?,?5??,??1??,???
- ??????,?????,??????
- ?????????????????
- ???????????
- ????,4?????,?2????
15(No Transcript)
16????
- ???????????????????????????????
- ???????,?????????????
- ????????????42?,3?5?7????????89?72?30
17??????????
- ????
- ????????????????,????????,???????,?????,???????
- ????
- ???????????,???????????????
18(?)?????????(Corynebacterium parvum, CP)
- ????,???????????,????????
- ???????,??????????
- ?????????,???????
19????????
- ?????????????????,????????????
- ??B????,???T????/??????????????
20????????
- ?T???????,???????????,?????????
- NK??????
- ????????????????
21????
- CP????????????30?
- ????6?(20)
- ????21?(70)
- ??3?
- ????90
22? ?
- 2-4mg/?,????,??2-3???????????
- ????-CP-????-CP-??????-CP-????????????10mg,????,?
???,CP 4mg/?,????
23????
- ????????????????????????????????????????????????
???? - ??????????,?????
24(?)???????????BRM,????????
- ?????0K-432(???picibanil)
- ?????722,?????(sapylin)
- 0K-432?Sapylin????????A?Su????
25OK-432????????
- ????????????????T??????????,????????????????NK???T
?? - ?????????????,????????
-
26OK-432????????
- ????????????T???????,?????
- ???????NK?????????
27??????
- ?????????27?????
- CR3?,PR16? ,NR8?,???70
- E.Kubata(1993?)?0K-432????????????,????????????19?
,??6?(6/19),????9?(9/19),????88
???,?
28? ?
- ????0.5?1.0?2.0?5.0KE(1KE???0.1mg????)
- ???????????????????
- ?????0.5KE??,????,???1-5KE??
- ????1.????2.???????(????????)
29????
- ??(38???),???1-6??,24???????
- ??????????????
- ?????????
- 30???????
30??????
31(?)?????2(Interleukin-2, IL-2)
- ??????,T??????
- ???????IL-2(?hIL-2)
- ???????????
- ????????????
-
32??????
- ??T???????
- ?????T?????????????????(LAK)??,?NK????????
- ?????IL-2,????????????????????,??????????
- IL-2????B??,?????
33????
- ??????????????????????
- ????????,????????????,????????
- IL-2??????????????(?51-80)???????????????????????
????????
34(?)???(Interferon, IFN)
- ?????????,????????(????)
- ???????????
- ????????,??a?ß????
- IFN-a?????????(I????)
- IFN-ß???????????(II????)
- IFN-??????,???????(III????)
35IFN??????
- ??????????????????????
- ??????????????IFN??????????,??????????
- ???????????????????????????????????,??????,????
???,???????????????????????
36??????
- ???????????,?????????T????????
- ???K?NK?????????????
- ???????,??????????
37? ?
- 1-6106IU,???????,????,???????6-12 ??
- ????IFN?????? ???IFN?????NK????????????IFN?????,?
?????
38????
- ??????????,?????????,????????????????????2-4??,?
?38-40?,???????????????? - ??????????????
39 IFN????????
?? ?????()(CRPR) ?? ?????()(CRPR)
?????? 90 ???? 60
??????? 73 ????? 80
????? 44 ????? 93
??????? 65 ??? 48
??T????? 90 ?(?)?? 38
?????? 80 ???? 75
??? 50 ????? 35
???? 75 ??? 75
40(?)????(Transfer factor, TF)
- ???????,????????,???????,TF???????????
- ????
- ????????????????? ????????????????DiGeorge?
??? -
41(?)????(Transfer factor, TF)
- ????????,???????????,1108???????/????1-2?,????
- ????????????????
- ??????????
-
42(?)???????
43(?)?????
- ?????????????????,???????
- ?????????????(???),??????????
- ???????????????????,?????????????????,???????
-
44(?)????????? ????
- ??T??????????????????
- ????????Na/H??????,????PH?,????????????
- ????????,????????????
-
45????
- ???????????,????????
- ????????,????????????
46????
- ?????,???4.0109/L??
- 1-1.5µg/kg/d,????,??1-2?
- ???2.0109/L??,1-2µg/kg/d,2-3?
- ???2.0109/L??,2.5-5µg/kg/d,5-7?
47(?)????????
48????? T ??????
T ????
????
????
???
?? ??
??? PHA ?????
??? ??
??????
??????
49?????????? ??
- ??2.17cm ??
- ?????1010950
- ?50,000(?)107
50(?)???????
51(??)??(DNA)????
52??????????
??????