1. ???(arecoline) ,????(arecaidine)

1
??????????????

• ??????????????
• ???

2
??????????
3
????

• 1. ????---?????????
• 2. ????---??????????

4
?????????

• 1. ????
• 2. ????
• 3. ????
• 4. ????
• 5. ???

5
????????????

1. ??????
2. ???

6
?????????

• 1. ???(arecoline) ,????(arecaidine)
• 2. ?????????,????(nitrosamine)
• 3. ???????????????????????????????
• 4. ???????(safrole)

7
???

• 1. ?????
• 2. ???

8
?????

1. ???????????
2. ?????????
3. ?????88???????
4. ???????? 2200?
5. ???????? 4000?
6. ????????????????
7. ????????????????

9
??????

• 1. ???
• 2. ????
• 3. ???
• 4. ????
• 5. ???????

10
????

• 1. ???
• 2. ???
• 3. ????????
• 4. ????
• 5. ???

Homogeneous leukoplakia ????
Non-homogeneous Leukoplakia ?????
11
?????

• 1. ??? --- ?0?
• 2. ??? --- 1-7?
• 3. ???????? --- 4 - 15?
• 4. ??? --- 28?(18 - 47?)
• 5. ?????? --- 4 - 11?
• 6. ?????? --- 20 - 35?

12
????????

• 1. ????????? --- 90?
• 2. ???????? --- 5?
• 3. ???? --- 5?

13
?????
14
????????

• 1. ????????? --- 10?
• 2. ?????????? --- 40?
• 3. ???? --- 50?

15
?????????

• 1. ??????
• 2. ????
• 3. ??????
• 4. ?????

16
???????

• 200???

17
?????????

• 1. ??????3?
• 2. ?????6-8??

18
???????????

• 1. 10??? --- 2.3?????
• 2. 15??? --- 4.5?????
• 3. 17??? --- 7.6?????

19
?????????????

• ?????
• ??????
• ????
• 3. ??????
• 4. ??????

20
1????????

1. ? DNA ????????
2. ???????????

21
1 Toluidine blue solution

1. Toluidine blue O powder ----- 1 g
2. Acetic acid ------------------- 10 ml
3. Absolute alcohol ----------- 4.2 ml
4. Distilled water -------------- 86 ml

22
1 Toluidine blue vital stain

• Procedures for toluidine blue vital stain
• 20 ml 1 acetic acid -- oral rinse for 20 sec
• 10 ml 1 toluidine blue solution oral rinse for
  30 sec
• 20 ml 1 acetic acid -- oral rinse for 20 sec
• Clean water oral rinse several times
• Evaluation of the lesion deep-blue stain
  represents positive result.

23
1 Toluidine blue vital stain
False positive reactions can occur due to dye
retention by filiform papillae and oral ulcers,
as well as mechanically in fissures.
24

• Thank you
• for
• your attention.