Title: ???(vitamin)????????????,??????????????,???????????????????
1??? ??????
???
2??? ?????
????
- ???(vitamin)????????????,??????????????,?????????
??????????
- ???????,?????????????????????????,????????,???????
- ?????????????????(?????)?
3?? ??
???????
- ?????A?B?C?D???,????????????????????,??????????
????????
1967?1970?????????????????????????V???????,???????
???
4????
????????,????????,?????????????????(lipid-solub
le vitamins)???????(water-soluble vitamins)????
5??? ??????
????????B????????C??????????????????????,??????
???,??????????????????????,?????????????
6 ?????Bl (???)
(?)????????????????
7(?)????-??????(TPP)
???ATP ? TPPAMP
8(?)????
? B1?????TPP,????????a-? ?????????,??a-?????
? ????????????,??????
CH3COCOOH?CH3CHOCO2
? ???????????
? ??????
9(?)???Bl???
- ?TPP???????,?VB1,TPP????,??????????a-???????????,?
????,????????????????????????????
- VB1??????????,?????B1?,??????????,????????,???????
??,???????????????????????????????
10 ?????B2
- ???B2?????(riboflavin),??????????????????
11(?)???B2??
???
????
12???B2??????FMN?FAD
FAD?????????
FMN??????
13(?)????????
????FMN?FAD??????????????
14- ???B2???,???????????????????
- ????????1.21.5mg,????????????????????????B2????
15????
(?)??
???????????B3?
16??ACoA?ACP(??????)???????????
17(?)????
???C0A?ACP??????????,??????????????,?? 70????
C0A? ACP?
18 ?????B5
(?)?????
???B5?????PP????(?)?????,?????(nicotinic
acid)?????(nicotinamide),?????????
??? ????
19- ???PP????????,?????????????PP,??????,?1/60,?60mg?
??????? lmg??????????????,????????PP?????????
20???PP????????
NAD NADP
?????????? ????????????
21- NAD? NADP???????????????,?????????????????????
???
22?????B6
(?)??
???B6?????????????,?????????????????????????????
,??????
23(No Transcript)
24(?)????????
- ??????????????????????,???????????????????????
- ?????????????,???-???????,?-?????????????????????
??B6???????????????
- ????????B6????????????????????,?????????,????????
?,??????B6?
25?????
???(biotin)??????B7????H,????????????????,??????
?????????,??????,????????????
(?)?????
26(?)????????
- ??????????????,????????,??CO2?????
- ??????????????????????????????,??????????,???????
?????????????????,????????????
27????
(?)?????
- ??(folic acid)?????????????,???????????B11?
285.2 ??????-??
29(?)????????
- FH4?????????????,???? N5? N10
?????????????????????????????,???????????????????,
DNA????????,??????DNA????,????????,??????,????????
??
30- ???????????????,?????????,???????????
31- ???????????????????????????????????,???????????
32?????B12
(?)??
???B12?????(coholamine),????????????????B12?????
??????,????????,????????????????5-???????,???????
?B12????,?????????????
33??? 5-???????
34(?)B12????????
35?????
????????????a-??????????????????????,???????,??
????????? ?????????
36?????C
(?)?????
- ???C??????(ascorbic acid)???? C2?C3???????????????
???? H,?????,?????????, C2? C3???????????????????
??????
37- L-?????????????
- ????????????????
- ?????????C,???C?????????????,????????????????????
,????????????????C?????????????????????C,????????,
?????????C??????
38(?)????????
1.?????????????????????????????????,?????,????????
?????????????
2.??????????40???????????C?????????7-a???????7-a-
???????
39 3.???C???????????????????????,???????????????????
?,?????C???? C???,?????????????
4.????C???,?????????
405.???C??????????
- ???C??????????,???????-SH???????
- ???C?????????????(MHb)???????(Hb),??????????
- ???C??????A?E????,???????????????????????????????
?60mg?
41??? ??????
?????A
(?)??
- ???A????????????????A????? A1? A2 ?
42- Al?????,???A?????????????????,???????????
- ?????????A,??ß-?????1??ß-????????2?????,?????ß-??
???????A??
43?????A?????????????? ????????????????????????
44?????D ?????D??????????? ????????,???
45VD????????? ??????????
46?????E(???) Evans 1922 ?? ?????E?????????????? ??
?????????
47????(??????)
48?????K(?????) ???????????????? ?????K???????????
??????????
49?????????????
- ??? ??
?? - 1. B1(???) TPP
a -?????? - 2. B2(??? ) FMN?FAD
??? - 3. PP ???(??) NAD?NADP
??? - 4. ??(???) CoA
???? - 5. B6 ???(???) ?????(?) ????????
- 6. ??
FH4(THFA) ?????? - 7. ???
???? - 8. C(????)
?????? - ???
???????? - B12(????)
????? -
??????
50The end