Immunogenetics

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• Immunogenetics

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• ????
• ????????????????????
• ?????????????????????????????????????????????????

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?????????
(?)ABO????

• 1. ABO?????????????

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(No Transcript)
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2. ABO?????
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(No Transcript)
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(No Transcript)
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(No Transcript)
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(No Transcript)
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• (?)Rh????????
• Rh?????

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• ???????1???????D?CE???D??????D???CE??????C?c?E?e?
  ?,????????????,????????1-2????????D???????????????
  ??,??Rh(-),???Rh()?

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(No Transcript)
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(?)??????

• ??????????????,??????????????
• 1?ABO??????
• ???O?????A?? B????

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• 2?Rh??????
• ???Rh(-)???Rh()???

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??????????
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?????????

• (?)HLA(Human Leucocyte Antigen)?????
• ???6p21.3,?????????(polymorphism)???????,?????????
  ?????

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(No Transcript)
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• (?)??????

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(?)HLA?????

• ???????,????????????????????????,?????????????????
  ??????????????????????????????????????????????????
  ????

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1?????

• ???????????????ABO?????HLA????,?????????????,?????
  ?????????????,???????(histocompatibility),??????
  ???

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• 1)????

a)ABO????
b)Rh???? Rh()???????Rh(-)???
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• 2)??????
• ????(autograft)
• 
  ????
• ????(isograft)(??????)
• ??????(allograft,homograft)
• 
  ?????
• ????(xenograft)

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• ???(???????)
• (a)ABO?????,???????
• (b)HLA????????????????????HLA?????HLA???(HLA
  haplotype)?????????HLA??????HLA????

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(No Transcript)
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• ?????
• ????
• ?????????
• ??HLA??????
• ??HLA?????????
• HLA??????????
• ????HLA????????
• ?A?B?DR???6?????,??????HLA???????

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• (c)????????
• ??????(T?B) ???? ??
• T() B()?????????HLA??I??????-----????
• T(-) B()?????????HLA??II??????------?????

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• ????(??????)
• ???????????
• ?????????(??),???????????(??),????????(graft-versu
  s-host disease, GVHdisease)??,??????????????