P1254503583wvnaV - PowerPoint PPT Presentation

Title: P1254503583wvnaV


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Transmission electron micrograph of an interface
between glass-ceramic A-W and rat tibia 7 d after
implantation.
2
SEM picture of glass-ceramic A-W implanted into a
tibia of rabbit as a function of time after
implantation.
3
Transmission electron micrograph of an interface
between glass-ceramic A-W and rat tibia 14 d
after implantation.
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The essential requirement for artificial
materials to bond to living bone is the formation
of a bonelike apatite layer on their surfaces in
living body.
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SiO2
Apatite formation No apatite formation
Dissolution
20
80
60
40
Glass formation
40
60
20
80
20
40
60
80
CaO
P2O5
mol
Compositional dependence of apatite formation on
the surface of glasses in the CaO-P2O5-SiO2
system after soaking in SBF for 28 days.
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Cancer treatment
Resection of tumor (Surgical method)
Difficulty in recovery of function of resected
organs
Development of cancer treatment method without
resection
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Conventional radiotherapy
External irradiation

• Little irradiation dose to tumors
• Damages to healthy tissues

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89Y
90Y
Neutron bombardment
b-emitter

Half-life 64.1 h
17Y2O3-19Al2O3-64SiO2 (mol) glass
microspheres(2030 µmf)
Y2O3-Al2O3-SiO2 glass microspheres for
radiotherapy of cancer. (after G. J. Ehrhardt et
al., Nucl. Med. Biol., 14 (1987) 233-242)
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Radioactive microspheres (2030 µmf)
b-ray
Aretry
Catheter
Tumor
Cancer treatment with radioactive microspheres.