MMX

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• MMX
• Multi Matrix System
• Presentation

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DisclaimerImportant Notice

• For the use of the recipient only. Not to be
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  available information, internally developed data
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  accepted by Cosmo or by any of its officers,
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• This presentation does not constitute an offer,
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  subscribe for or issue any securities or a
  solicitation of any such offer or invitation and
  shall not form the basis of any contract with
  Cosmo. Opinions expressed herein are subject to
  change without notice. In providing this
  presentation, Cosmo undertakes no obligation to
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  omissions which may become apparent.

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Drug Delivery Platform

• New oral delivery technology
• Designed for off-patent drugs
• Focus on inflammatory bowel diseases
• Scaleable/low cost of goods

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The Drug Delivery Platform
Multi Matrix System (MMX )
Inert matrix
Hydrophilic matrix
Gastroprotectant layer LV hydrophilic -
amphipatic polymer matrix HV hydrophilic
polym. matrix inert matrix material drug (
excipient)
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MMX - Release of active ingredient

stomach
Duodenum

Dejunum

Ileum
Colon

Time
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IBD medications sites of actionMMX tablets
vs. other dosage forms
Site of action
enemas
MMX tablets
Oral dosage forms
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3h 30 ileum
1h 30 small intestine
4h 30 ascending colon
10h trasverse colon
7h 30 trasverse colon
15h descending colon
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MMX
16h descending colon
24h rectum
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MMXLow absorption after single dose
administration in Drug () and Metabolite (o)