QUINOLONES

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QUINOLONES
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ADVANTAGES OF NANO DRUG DELIVERY FOR TREATMENT
OF TUBERCULOSIS

• Reduce the dosage of antituberculosis drugs
• Reduce dosage frequency
• Minimise the toxicity of drugs
• Reduce the cost of TB treatment
• Improve patient compliance

Targeting antituberculosis drugs in infected
Macrophages
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DESIGN OF TARGETED DRUG DELIVERY SYSTEMS ON THE
BASE OF PLGA-NANOPARTICLES
PLGA (?oly(D,L-lactide-co-glycolide)
Scheme of polymeric nanoparticles preparation
by emulsification method
Chemical structure of PLGA
Metabolism of PLGA and PLA
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ANTITUBERCULOSIS ANTIBIOTICS FOR PREPARATION OF
DRUG-LOADED NANOPARTICLES
Cycloserine
Rifampicin
Cycloserine 12.5 PLGA-COOH (50/50) 50
Practicle Size 30967 nm
Rifampicin 8.5 PLA 59 Practicle Size
30071 nm
Protionamide 8.4 PLGA (50/50) 59 Practicle
Size 36770 nm
Capreomycin 8.5 PLGA (50/50) 59 Practicle
Size 35855 nm
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COMPARATIVE TOXICITY OF ANTIBIOTICS ENCAPSULATED
INTO PLGA NANOPARTICLES (IN BALB/C MICE)
General toxicity of nanoform of antibiotics was
decreased as compared to free form of
antibiotics
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