African Traditional Medicine Herbal Product

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African Traditional Medicine Herbal Product
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Nigerian scientists have developed an animal
model which demonstrates that Jobelyn
Supplement lowered Neuronal Degeneration. The
team of scientists led by Oyinbo A. Charles
Department of Human Anatomy, Faculty of Basic
Medical Sciences College of Health Sciences,
Niger Delta University Wilberforce Island,
Bayelsa State (Nigeria) in an interview said
that  Alcohol-induced neurodegeneration, a
consequence of chronic ethanol exposure, is a
neuroadaptation that drives the progression of
alcohol use disorder (AUD).
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Unfortunately, conventional drugs for AUDs do not
prevent neurodegeneration as part of their
pharmacological repertoire. Multimodal
neuroprotective therapeutic agents are
hypothesized to have high therapeutic utility in
the treatment of central nervous system.
Interestingly, nutraceuticals by nature are
multimodal in mechanisms of action. Purpose This
study examined the neuroprotective potential of
Jobelyn in prefrontal cortex (PFC) of a
binge-alcohol rat model of AUD. 
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he result of the animal experiment showed that
Jobelyn supplementation significantly lowered the
levels of histologic and biochemical indices of
neurodegeneration, and caused an increased
expression of p53 protein and a decreased
expression of NSE immunoreactivity (NSE-IR).  The
scientists concluded that Jobelyn supplementation
ameliorates neurodegeneration in the PFC of AUD
rats by reducing the oxidative stress, reducing
the NSE-IR, and by increasing the expression of
cellular tumor antigen p53 in the cortical neurons
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Explaining why this study was very important Dr.
Oyinbo said that  Excessive alcohol ingestion,
characteristic of alcohol use disorders (AUDs),
results in neurodegeneration, which is
responsible for the cognitive and behavioral
impairment that drives the transition to alcohol
addiction  . Globally, about 80 million people
have diagnos-able AUDs, making it a major global
health concern. To date, renowned medications for
the treatment of AUDs acamprosate, disulfiram,
and naltrexone, have been clinically
unsatisfactory.
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They targeted the psychoactive properties of
alcohol while the neurodegenerative effect of
alcohol that drives alcohol-induced neurological
dysfunction was not managed by these specific
remedies. The prefrontal cortex (PFC) is highly
susceptible to alcohol-induced damage . PFC
deficiency is characterized by executive
dysfunction such as deficits in working memory,
impulse control, and decision making. They are
linked with the inability to abstain from
alcohol. Executive dysfunction often occurs
before general mental status challenges. Studies
showed that chronic alcohol exposure is related
to the induction of oxidative stress and
neuroinflammatory mediators
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which lead to neurodegeneration. Consistent with
this hypothesis, antioxidants have been effective
in reducing binge alcohol-induced
neurodegeneration. Neuroprotection mediated by
antioxidant treatment is associated with the
inhibition of nuclear factor kappalight-chain-enha
ncer of activated B cellsDNA binding, reduction
of cyclooxygenase-2 (COX-2) expressions, and
microglial activation which support the
hypothesis that neuroinflammatory signalling and
oxidative stress contribute to alcohol-induced
neurodegeneration. Jobelyn (Health Forever
Products, Lagos, Nigeria), a commercially
available nutraceutical, has shown outstanding
anti-inflammatory and anti-oxidative properties
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