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TRIGR ??I?????????? ??-???? DIPP ???????????
??-????
3
????-????
DPT-1 ???????-1 ??-???? ENDIT ????????????? ??,?
??-????
4
????
DQB10302?/?0201 -TRIGR,DIPP ?DQB10602/3?301
(??) -DPT-1,???ICA??????? ????? -ENDIT
5
????
???????? -DIPP?? ??????????????????????? ??gt1/2
???? ????????????
6
??????
Beta??????(BCA) -??????(ICA) -??????(GAD) -??????
??(IA-2) -???(IAA) ????????
7
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ICA????(??????)???I???? ICA??????????????DQ?????
-??? 12????????gt30 Pietropaolo,2000
8
Beta??????
??I????(?90)?????1?BCA???? ????????? ???????1
I??????????BCA????????? 2?BCA-?????65
3?BCA-???gt90
9
??????
????? -TRIGR,DIPP ICA????????? -DPT-1,???ICA????
?ICA?? -ENDIT
10
I????????
?? ?? ????/??
TRIGR ??? FDR/??
DIPP ???(??) GP/??
DPT-1 ???(??,??) FDR/ICA/??
ENDIT ???? FDR/ICA
CM??,FDR????,ICA??????,P??,O?,N?,GP????
11
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???? ?????,?????????????????,???????????????????,
????????? ??????? ???????????????????????,????IAA
??
12
?????????
????????????,?????? ????????????CM?BCA?? ??????
?????????????????
13
DIPP??
????4? ??????? ????70 ????????BCA??/I??????
??????????????????????????????? Diabetologia
44290-7.2001
14
TRIGR ??
CM HC BF
?? N58 N61
????? 1.9? 3?
?? 4.8? 3.6?
IAA 2 1
3? N14 N9 N17
SI?BI 2.2 1.8 1.6
IgG?BI 0.21 0.13
????????? plt0.05 ( Diabetes 491657-65,2000)
15
TRIGR?????
??????????????????,??????????????,???
-????30???? -?70???????
16
TRIGR??
??????????173? ??6-8? ???ICA????????? 3.6?11.
2,p0.06 ??1.9?12.5,plt0.04 American Diabetes
Association,1999
17
DIPP??
22??????I???? 12???DIPP?? 3???
7???????(32) ????????????5?(23) Diabetologia
44290-7,2001
18
????? ????
??????????????????I????????? ??????? -Beta??????
?? -???? -????
19
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?????????????????? ??????????????I???? ????????
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20
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??????????????? ?????????????????????
21
DPT-1
???????(gt50)????????5?????I??????????35 ??1?
?2???3? ??ICA,IV/OGTT, IAA, DQ ????? 2X/?,IV
1X/? ??????
22
DPT-1
???????(25-50)????????5?????I??????????35 ??
1??2??? 3? ??ICA,IV/OGTT, IAA,
DQ ????????? ??????
23
?????????
??gt89,000?? 3.5?ICA?? ??339???? ????4-45???
?11? 5?? ?60?????????I???? ???????,2001
24
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??????? ??????????? ?????? -????? -?????
-???????? Oral insulin arm is still
recruiting ???????,2001
25
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I??????/??????
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-????????? -????????????????????????
28
?????
????????????I?????????? M Trucco,
PI ??DOD??????????????HLA????
29
??DOD??
Trucco?????????????I??????? ??????? ???HLA
DR-DQ ???BCA,TCR V