Cooleys Anemia

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Cooleys Anemia
This learning stack was researched , designed,
and created by
Johnny Ly
Florin High School Biology Miss Haugen 1998
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Table of Contents
1. Introduction 2. Mode of Inheritance 3.
Clinical Description 4. Treatment 5.
Prevention 6. Detection 7. Glossary 8.
Bibliography 9. Credits
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Introduction
The name of my disorder is Cooleys anemia,
also known as thalassemia. Cooleys anemia or
thalassemia is a blood disease, one of the
commonest inherited diseases- especially in the
Mediterranean region and south Asian regions.
Death occurs in the teens or the early twenties
because of anemia or heart failure.
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Mode of Inheritance
Cooleys anemia is inherited as an autosomal
recessive genetic trait. The gene that cause
thalassemia is located on the short arm of
chromosome number eleven. People who have both
of the pair of genes that cause thalassemia have
more severe symptoms than people who has only one
of the pair of genes that cause this disease.
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Clinical Description of the Disorder
What Cooleys anemia does is that it causes red
blood cells to be small called Hemoglobin.
Hemoglobin gives blood its red color and carries
oxygen throughout the body. Hemoglobin is made up
of four chains, two called Alpha and the other
two called Beta.
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Treatment
To treat this disorder what the doctors usually
do to their patients is provide them with regular
blood transfusions to keep the level of
hemoglobin high and maintain the supply of oxygen
to the tissues. The bad part about this is when
there is frequent blood transfusions it can cause
iron build up and the patients may need to be
treated with a special drug which allows the iron
to be excreted safely in the urine.
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Prevention
The only way to prevent this is go to genetic
counseling and determine if two people have the
genes for Cooleys anemia. If found one out of
four of the children are expected to have this
disorder. What can also be done is after twenty
weeks of pregnancy is examine the blood and see
if any beta chains are being produced, if not
its likely the baby have the disorder.
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Detection
Cooleys Anemia symptoms maybe present at birth
or not apparent for years in the human body.
Symptoms may include fatigue and yellow
appearance to the skin. Children may also
experience fever, headache, and loss of appetite,
vomiting, leg sores, and general weakness.
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References
Thalassaemia Encyclopedia, page
2313. Rucknagael, Donald L. Cooleys Anemia,
Grolier electronic publishing, 1993. 71
Thalassemia Major, Mediterranean Anemia, Cooleys
Anemia, National Organization for Rare
Disorders, Rare Disease Database, 1993. Alpha
Thalassemia, Kasier Permanente Booklet contact
Genetics Dept. [phone] Cooleys Anemia,
Progress in Biology and Medicine. Internet
Source www. Nhibi.nih.gov/ nnlbi/
blood/other/prof/cooleys2.pdf.
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Glossary
1. Hemoglobin the red coloring matter of the red
blood corpuscles of vertebrates, a protein
yielding heme and globin on hydrolysis. It
carries oxygen from the lungs to the tissues and
carbon dioxide from the tissue to the lungs. 2.
Polypeptide a substance containing two or more
amino acids in the molecule joined together by
peptide linkages. 3. Malaise a vague feeling of
physical discomfort or uneasiness, as early in a
illness. 4. Dyspepsia impaired digestion
indigestion.
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Glossary
5. Jaundice an condition in which the eyeballs,
the skin, and the urine become yellow. 6. Anemia
reduction in red blood cells. 7. Thalassaemia an
inherited anemia found among people resulting
from faulty hemoglobin production. 8.
Transfusion the act or and instance of
transfusing. 9. Inherit to receive by the law of
inheritance from the ancestor at his or her
death. 10. Foetus same as fetus,
pregnant.
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Credit Card
This stack was researched, designed, and created
by Johnny Ly