Integument skin

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Stephen E. Fish, Ph.D. Mitchell L. Berk,
Ph.D. Marshall University J. C. E. School of
Medicine
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Note to instructors I use these PowerPoint
slides in histology lectures that I give to first
year medical students. Copy the slides, or just
the images into your own teaching media. We all
know that teaching science often requires
compromises and simplification for specific
student populations, or the requirements of a
specific course. Please feel free to offer
suggestions for improvements, corrections, or
additional illustrations. I would be pleased to
hear from anyone who finds my work useful, and am
always willing to make it better. Also, the
images have been compressed to screen resolution
to keep PowerPoint file size down, and I can
provide them at any resolution. Contact me about
the illustrations and Mitchell L. Berk about the
photomicrographs. Stephen E. Fish,
Ph.D. Fish_at_Marshall.edu Berk_at_Marshall.edu
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Integument (skin)
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Skin layers
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Layers
Corneum
2 wks
Lucidum
Granulosum
Spinosum
2 wks
Basale
Dermis
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Stem cells the EPU (10-12 columns)
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Spinosum
Spiny prickle cells
Stretched desmosome attachments
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Melanin production cytocrine secretion
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Melanin in keratinocytes melanocyte
cytoplasmic processes
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Thin skin
Langerhans melanocytes
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Langerhans Cells in thick skin Merkel cells
would be in the basal layer
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Thick skin
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All layers visible in thick skin
Corneum Lucidum Granulosum Spinosum Basale
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Elaborate dermal elevations
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Dermal elevations help keep epidermis in place,
otherwise a blister forms
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Dermal elevations
Primary dermal ridge carries through to surface
Secondary dermal ridge
Papilla
Interpapillary peg
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Thick skin has meissners corpuscles in the
papillary dermis
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Pacinian corpuscle in the reticular dermis
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Thin skin
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Thin
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Thin skin dermal papillae
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Thin skin dermal papillae revealed
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Dermal vasculature
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Hair detail the pilosebaceous apparatus

• Pilosebaceous apparatus a hair, sebaceous gland
  arrector pili muscle
• Follicle sebaceous gland are epidermis, muscle
  is not
• Basal layer continued in follicle sebaceous
  gland
• Hard keratin binds together tightly to make hair
• Sebaceous gland cells full of lamellar bodies
  flake off just like skin
• The papilla at the bottom is like papillary dermis

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Melanocytes in the basal layer produce hair
color. Keratinocytes produce hard keratin
Melanocytes in the basal layer produce hair
color. Keratinocytes produce hard keratin
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Sebaceous gland hair follicle
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Pilosebaceous apparatus
Sebaceouos gland
Arrector pili
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Eccrine sweat glands
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Eccrine sweat gland
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Eccrine duct Interpapillary peg Sweat pore
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Fingernails are just a specialized region of skin
where hard keratin is the stratum corneum
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Fingernail terminology
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Sherman says