Polymers, Monomers, and Lipids

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Polymers, Monomers, and Lipids
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Proteins, Quoi?
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Protein Overview
Major constituent of most cells (gt50 dry weight)
Highly sophisticated molecules (or
multi-molecular complexes)
Extremely large number of unique proteins exist
They are polymers folded into specific
conformations (shapes)
Conformation functional-group chemistry
controls function
Made up of 20 different types of amino-acid
monomers
Proteins define what an organism is, what it
looks like, how it behaves, etc.
You are your proteins!
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Protein Function
http//fig.cox.miami.edu/cmallery/150/protein/pro
teinsb.htm
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Globular versus Fibrous
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Monomer (amino acid) Structure
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Amino Acid Ionization
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Amino Acid Types
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Peptide Bonds
Because of Resonance the backbone of
polypeptides has greater rigidity than otherwise
might be expected
Polypeptide backbones are more than just wet
noodles!
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Conformation Shape ? Function
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Protein Primary Structure (1/2)
Primary Structure is sequence of Amino Acids
Note the Polarity of the sequence (amino ?
carboxy)
Note also the Disulfide Linkages (cys-cys ? S-S
bonds actually considered a component of
Tertiary Structure)
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Protein Primary Structure (2/2)
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Protein Secondary Structure
These are interactions (H-bonds) between peptide
backbones
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Protein Tertiary Structure
Tertiary Structure is an interaction
between non-adjacent amino acid R groups
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Protein Quaternary Structure
Quaternary Structure is the interaction
between adjacent Polypeptides that make up a
single Protein
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Protein Structure Overview
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Protein Denaturation
Destruction of Conformation Loss of Function
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Protein Folding
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