CRISP AMI

1
CRISP AMI

• Objective
• To determine if routine intra-aortic balloon pump
  (IABP) placement prior to reperfusion in patients
  with anterior STEMI without shock reduces infarct
  size
• Study Design
• Randomized, open-label, multicenter, controlled
  trial
• 337 patients randomized to either IABP prior to
  PCI (n161) or standard PCI with bailout IABP
  (n176)
• Primary Endpoint
• Infarct size as measured by cardiac MRI
• Secondary Endpoints
• All-cause death at 6 months
• Vascular complications and major bleeding at 30
  days

2
CRISP AMI

• Results
• Mean infarct size was not statistically
  significantly different between the patients in
  the IABP plus PCI group and those in the standard
  PCI group (42.1 vs 37.5, respectively p0.06)

Primary Endpoint
3
CRISP AMI

• Conclusions
• Compared with PCI alone, IABP plus primary PCI
  did not result in reduced infarct size among
  patients with acute anterior STEMI without shock
• All-cause mortality at 6 months did not differ
  significantly between the two groups