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Glycolysis, Gluconeogenesis, and the

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Pentose Phosphate Pathway Beginning +aromatic amino acids + His. Pentose Phosphate Pathway (PPP) can start at several places. It is not a linear pathway and not a ... – PowerPoint PPT presentation

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Title: Glycolysis, Gluconeogenesis, and the


1
Chapter 14
Glycolysis, Gluconeogenesis, and the Pentose
Phosphate Pathway Part 2 Gluconeogenesis and
PPP
2
Gluconeogenesis and PPP Learning Goals.
  • Know
  • Entry to gluconeogenesis.
  • Glycolysis backwards which enzymes are at Eq
    and those that are the drivers.
  • What makes some amino acids glucogenic.
  • Pentose Phosphate Pathway entry by glucose-6-P
    and transaldolases, transketolases.
  • Why the PPP is a web pathway.

3
Gluconeogenesis Forms Sugars from Other
Metabolites
4
Going Forwards and Backwards
5
The Beginning of Gluconeogenesis
6
Pyruvate Carboxylase
7
PEP Carboxykinase
8
Pyruvate Actually Has Two Ways to PEP
9
The End of Gluconeogenesis
10
Gluconeogenesis Energetics
EOC Problem 21 overall energetics of Glycolysis
and Gluconeogenesis. EOC Problem 22 Concept of
a Futile Cycle.
11
(No Transcript)
12
Pentose Phosphate Pathway Beginning
aromatic amino acids His
13
NADPH and Oxygen Toxicity
SuperOxide Dismutase
14
PPP Beginning from Glucose-6-Phosphate
15
Lactonase
16
6-Phosphogluconate DH
17
Phosphopentose Isomerase (not an Epimerase)
18
Ribose-5-Phosphate Epimerase
19
PPP the Web like Pathway Stuck onto the Side of
Glycolysis
20
PPP Transketolases transfer 2 Carbon units
21
PPP Transketolases transfer 2 Carbon units
22
PPP Transaldolases transfer 3 Carbon units
23
Another Transketolase
24
PPP Arranged to Oxidize Glucose (6 in and 5 out)
6 Glucose-6-P
25
Control of PPP by NADPH
26
PPP Functions
  1. Produce Ribose-5-P for Nucleotide Synthesis
  2. Produce Ribose-5-P for His Synthesis
  3. Produce Erythrose-4P for Trp, Tyr, Phe Synthesis
    WYF
  4. Can Completely Oxidize Glucose
  5. Source of NADPH (Biosynthesis, Oxygen Killing
    System)
  6. Can be Rearranged to Calvin Cycle Fix CO2
  7. Other Specialized Reasons (Heterofermenters, etc.
    mainly in prokaryotes)

27
Things to Know and Do Before Class
  1. Entry to gluconeogenesis.
  2. Glycolysis backwards which enzymes are at Eq
    and those that are the drivers.
  3. What makes some amino acids glucogenic.
  4. Pentose Phosphate Pathway entry by glucose-6-P
    and transaldolases, transketolases.
  5. Why the PPP is a web pathway.
  6. EOC Problems 21, 22, 25 27.
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