Inflammation

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Inflammation
What is it? What are the stages, and occurrences
in those stages? Extensions?

• Human Biology

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Inflammation

• Attempt to restore balance in an area.
• Injurythe inflammatory response is initiated.
  Protective, defensive.

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Inflammation

• Etiologies
• Mechanical Trauma
• MVC (collisions), Knife Wounds, Gunshots,
  Surgery, twisting an ankle, knee.
• Foreign invaders (like bacteria)
• Toxins. Entrance though skin breaks (burn,
  splinter, wounds)

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Inflammation

• Symptoms
• Erythema
• Redness, heat
• Pain
• Edema (swelling)

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www.nlm.nih.gov/.../ ency/imagepages/2774.htm
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Inflammation due to gout
http//www.whathealth.com/gout/picture-3.html
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www.mf.uni-lj.si/.../ mullegger-4.jpg
Lyme Disease
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medstat.med.utah.edu/.../ mml/hrob_99502.html
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Lymphedema
Damaged, absent, malformed vessels
Note This is showing you an illustration of
edema, and not the entire inflammatory response.
http//meded.ucsd.edu/isp/1994/im-quiz/images/prim
edema.jpg
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Inflammation has five basic stages

• Vasodilation (And Increased Vessel Permeability)
• Phagocyte Migration
• Nutrient/Metabolic Increase
• Fibrin Formation
• Pus Formation

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Inflammatory Stages

• 1) Vasodilation and increased permeability of
  blood vessels.
• Histamine release does this at the site of
  damage. Pain from damages nerve endings.
• Chemical released during allergy, inflammatory
  response.
• Causes redness and swelling

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Inflammatory Stages

• 2) Phagocyte migration
• White Blood cells engulf and destroy bacteria and
  dead tissue.

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http//pathmicro.med.sc.edu/ghaffar/neutrophil.jpg
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http//www.sirinet.net/jgjohnso/macrophagephago3.
jpg
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Inflammatory Stages

• 3) Release of nutrients/Metabolic increase
• Need more energy to fight infection/wounds.
• Cellular respiration increase

Need more energy To deal with this
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Mechanically wounded epithelium forming New
junctions (arrow). (false color)
ls.berkeley.edu/bio/ gallery_mcb/wound.html
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Inflammatory Stages

• 4) Fibrin Formation
• Soluble protein called fibrinogen coverts to
  fibrin.
• Traps bacteria at the site to isolate
  infected/damaged area.

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http//www.chestpainperspectives.com/images/cpp_im
ages/Fibrin.jpg
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Inflammatory Stages

• 5) Pus Formation
• Thick fluid containing live cells, dead cells,
  bacteria, white blood cells.

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192.107.108.56/.../ pictureglossary.htm
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www.lhsc.on.ca/ wound/wounds.htm
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http//www.larve.com/Images/images_legulcers/magot
s_small-cavity_wound.jpg
Maggot Therapy
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Do you doubt the effectiveness of this treatment??

• The pictures you will see are proof that maggot
  therapy can help patients that have not responded
  to conventional therapy.

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Gangrenous ulcerations Patient was in hospital
for 5 weeks, receiving IV antibiotics and
surgery. Doesnt look too good.
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Two weeks later, after maggots have been applied.
See the healthy tissue? It is red and bloody,
but healthy.
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3 Months later An excellent result. The
scarring will fade over the coming months.
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Surgeons had a tough time figuring out which was
good tissue and bad tissue, due to the advanced
nature of the ulceration. They didnt want to
cut too much away. 3 years of foot ulcers in this
70 yr. old patient.
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After maggots were applied, the wound was
cleaned, and the dead tissue was removed. As you
can tell, the maggots did a much better job than
the surgeons could.
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After healing, the wound looks fantastic. Two
years afterwards, the wound had not reoccurred.
www.ucihs.uci.edu/com/ pathology/sherman/cases.htm

Last 7 slides are from Maggot Therapy Project,
University of California, Irvine.