Chemical libraries in the MSC:

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• Chemical libraries in the MSC
• ChemBridge(ChemBridge Corp.) -
  34,000 compounds (425 plates)
• - 34,000 selected from 1,000,000 to create
  maximum chemical diversity
• - Historical individually hand-made compounds
• LOPAC (Sigma-RBI) - 1280 compounds, (16
  plates)
• - marketed drugs
• - development candidates
• - gold standards with well-characterized
  activities
• Spectrum (MicroSource) - 2000
  compounds, (25 plates) lt20 overlap with LOPAC
• - Drug Components (50)
• - Natural Products (30)
• - Other Bioactive Components (20)

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• Chemical libraries in the MSC (continued)
• NIH Clinical Collections I and II (Evotec)
  - 727 compounds, (10 plates)
• - marketed drugs
• - molecules that have a history of use
  in human clinical trials.
• - highly drug-like with known safety
  profiles.
• Apex Library (TimTec) - 5040
  compounds, (63 plates)
• - A condensed Diversity library
• - Includes some Natural Products
• - Other Bioactive Components
• KIL80 Kinase Inhibitors Library (Enzo Life
  Sciences) - 80 compounds (1 plate)

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