Extracellular%20matrix

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Extracellular matrix

• Structure Function and Evolution of the

Graham Cromar and Dr. John Parkinson Program in
Molecular Structure and Function Hospital for
Sick Children Toronto, ON, CANADA
Committee Members Dr. Johanna Rommens Dr.
Andrew Emili Dr. Gary Bader
In the lab Dr. Jose Peregrin-Alvarez, Dr. James
Wasmuth, Chris Sanford,
David He
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Extracellular Matrix
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Aims
Map known disease genes onto the functional map
to understand how the ECM is involved in health
and disease.
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Methods
Protein Databases
Ensembl
RefSeq
Uniprot
Filter
Render
Interaction Databases
DIP
BioGRID
Database of ECM proteins
IntAct
Search
Mint
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The network was constructed, then expanded using
orthologues
Mouse 2268 Rat 1910 Human - 1165
Human - 2252
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Interesting biological results?
8,3,1,2,4 18,12
14,8,17,25 5,7,6,9
5,6,11,12,23