Bild 1

1
FIG. S4.
FIG. S4. Sonicated S. mitis dose-dependently
inhibit the production of TNF, IL-12 and IFN-? in
response to intact S. mitis. PBMC from six blood
donors were stimulated with 3 107 bacteria/ml
of S. mitis CCUG 31661 and graded concentrations
of sonicates of the same bacteria were added.
Cytokines were measured in the supernatant after
24 h (TNF, IL-12, IL-6, IL-8 and IL-10) or 5 d
(IFN-?). Medians and quartiles are shown by boxes
and the bars represent the 10th and 90th
percentiles, respectively. The response to intact
bacteria with and without addition of sonicated
bacteria was compared using Wilcoxon matched
pairs test. p lt 0.05.