Diapositiva 1

1
Osteoarthritis in the third millenium a new era
for an old disease. Semin. Arthritis Reum.
2005
2
Osteoarthritis
3
Osteoarthritis
4
Heat shock proteins and their roles in
chondrocyte protection ,an aplication for
autologous transplantation. Sawaatzky D A et al.
Immunopharmacolo- gy.2005 Safety study of
intrarticular injection of interleukin 1 receptor
antagonist in patients with painful knee
osteoarthritis a multicenter study.Chevalier X.
et. al. J. Reumatol.2005 The protective effect
of licofelone on experimental osteoarthritis is
correlated with the downregulation of gene
expression and protein synthesis of several major
cartilage catabolic factors MMP-13,cathepsine k
and aggrecanases. Arthritis Research Therapy
.2005 Sinovial tissue inflammation in early and
late osteoarthritis .Benito M. J.et. al. Ann.
Rheum. Dis.2005
5
PROTEOMICS

• Proteomics in Rheumatology , a new direction for
  old diseases. Ali M. et.al.
• Semin. Arthritits Rheum. 2005
• Proteomics characterization of human normal
  articular chondrocytes, a novel tool for the
  study of osteoarthritis and other rheumatic
  diseases. Ruiz-Romero C. et.al.
• Proteomics 2005

6
Gene Therapy

• Osteoarthritis gene therapy . C.H.Evans
• et.al.Gen. Ther.2004
• . Gene transfer to the human joint ,progress
• toward a gene therapy of arthritis.C.H.Evans
• Proc.Natl.Acad.Sci. 2005
• . Novel biological approaches to the
  intra-articular treatment of osteoarthritis
  .C.H.Evans.BioDrugs.2005
• .Gene therapeutics approaches transfer in
  vivo.C.H.Evans.Adv.Drug.Deliv.Rev.May.2006

7
Osteoarthritis

• The burden of this disease will increase in
  direct proportion to the increase of the older
  population..
• The major barriers to progress are financial
  rather than intellectual or technical.