Presentation ICM

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Opening autumn 2010
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ICM key words

• Scientific excellence
• External Scientific Advisory Board
• International recruitment of investigators
•  At the service of patients 
• Clinical Research Center, cohorts of patients
• Biological resources DNA, brain tissue, CSF,
  biopsies, ...
• Multidisciplinary approach
• From molecular biology to behaviour
• Core facilities
• Industrial partnerships
• Bioincubator, start-up facility
• Scientific cooperations
• Private Foundation public-private cooperation
• Entrepreneurial spirit

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The ICM scientific program finding new treatments

• Mechanisms of cell death
• Neurodegenerative disorders and ageing
• Neural code, synaptic transmission
• Epilepsy and related disorders
• Neurodevelopment, glial cells
• Multiple sclerosis and related disorders
• Neuronal bases of movement,cognition and
  emotions
• Parkinson, Alzheimer, depression, schizophrenia
• Neuronal plasticity, repair
• Brain and spinal cord trauma

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Pitié-Salpêtrière University Hospital
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The ICM 22,000 sqm
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ICM 600 investigators

• Engineers technicians

• Researchers

• Administration

• ClinicalInvestigationCenter

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ICM International Committees

• Scientific Advisory Board
• Gyorgy BuzsakiMolecular Behavioral
  Neuroscience, Rutgers University, Newark, USA
• Ray DolanCognisciences, University College of
  London, UK
• Marie FilbinNeurobiology, Hunter College, New
  York, USA
• Ann GraybielNeurophysiology, Massachusetts
  Institute of Technology, Boston, USA
• Dimitri Kullman Neurophysiology, University
  College of London, UK
• Nikos K. Logothetis Neuroimaging,
  Max-Plank-Institute, Tübingen, Germany
• Pierre MagistrettiBiochemistry, Lausanne
  University, Switzerland
• Bertram Müller MyhsokCell biology, Max-Planck
  Institute, Munich, Germany
• William D. RichardsonNeurobiology, University
  College of London, UK
• Giacomo Rizzolati Neurophysiology, University of
  Parma, Italy
• Peter St George-HyslopNeurogenetics, University
  of Toronto, Ontario
• Martin SchwabBiology, Zurich University
  Switzerland
• Michael ShelanskyNeuropathology, Columbia
  University, New York, USA
• Patrick Vuilleumier Psychiatry, University
  Hospital, Geneva, Switzerland
• Frank S. WalshPharmacology, Kings College,
  London, UK
• Frauke Zipp Neuroimmunology, Universitätsmedizin
  Berlin, Germany

• Honorary Committee
• Richard Axel (Nobel Prize)Columbia University
  (USA)
• Alain BerthozCollège de France
• Sydney Brenner (Nobel Prize)University of La
  Jolla (USA)
• Jean-Pierre ChangeuxCollège de France
• Martin Chalfie (Nobel Prize)Columbia University
• Pierre ChambonCollège de France
• Jacques GlowinskiCollège de France
• François Jacob (Nobel Prize)Pasteur Institute
  (France)
• Eric Kandel (Nobel Prize)Columbia University
  (USA)
• Michel LazdunskiFrench Academy of Sciences
• Nicole Le DouarinCollège de France
• Jean-Marie Lehn (Nobel Prize)Collège de France
• Stanley Prusiner (Nobel Prize)University of San
  Francisco (USA)
• Torsten Wiesel (Nobel Prize)Rockefeller
  University (USA)

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NeuroBioSource clinical and biological
resourcesin the field of neurology, psychiatry
and ophtalmology

• Cohorts of patients (100,000 per year)
• Multifactorial, monogenic
• Anamnesis, neuropsychology
• Tridimentional neuroimaging
• Genetics
• DNA samples (gt 50 disorders)
• Neurology 34,000
• Ophtalmology 2,000
• Psychiatry 3,300
• Brain bank
• Alzheimer, Parkinson, ALS, MS
• Depression
• Age related macular degeneration
• Rare disorders (Creutzfeld-Jacob, ...)
• Tumors of the nervous system
• Benign
• Malignant
• CSF samples
• Nerves and muscles biopsies

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ICM translational research
Clinicians
Clinicianresearchers
Researcherclinicians
Researchers
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ICM industrial partners intellectual property
Start-upFacilities
Laboratory space
Intellectual property office
Incubator
Industrialpartners
ClinicalResearch Center
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ICM Training and teaching
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Part of the regional neurosciences environment

• City of Paris

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National and international neurosciences
environment
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ICM public-private partnership

• Partners
• Ile-de-France Region, City of Paris,
• Assistance Publique- Hôpitaux de Paris,
• Caisse des Dépôts, Ministry of Research,
• Inserm, CNRS
• Industrial partners
• Private donors

• Calendar
• January 2008 ? June 2010 Building
• Autumn 2010 ? Opening

• Legal Status
• Private foundation designatedof public utility

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Opening autumn 2010
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ICM an international Institute of neurosciences
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ICM the investigators

• Where do theycome from?

• Who are they?

• What arethe advantages?

• Concentration of scientific talents
• Outstanding core facilities
• Multidisciplinary approach(clinical research,
  biological research)
• Welcome fund
• Paris

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ICM an organization at the service of research
General Director
Finance Human resources Legal affairs Industrial
partnerships Fundraising Intellectual
Property Data Processing ...
40TEAMSOF RESEARCH
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Pitié-Salpêtrière Hospital where neurology was
born

• 1634 Hospice for beggars, cripples, abandoned
  children
• 1684 Prison for prostitutes
• 1837 Hospice for aged women (4,400 beds)
• 1882 JM Charcot first chair for diseases of the
  nervous system
• 1895 J. Dejerine, J. Babinski, P. Marie T de
  Martel, C. Vincent F.Lhermitte
• 1913 Pitié-Salpêtrière Hospital