Diapositiva 1

1
INNOVATIVE TECHNOLOGIES FOR PROFESSIONAL
TRANSDERMAL VEHICULATION MATRIPOR PLUSTM
2
TRANS-CUTANEOUS ABSORPTION PRINCIPLES

• Horny layer represents the main bio-mechanical
  barrier to the exogen substances penetration
  through the skin
• The main obstacle is the corneal-lipidic bilayer
  organized in lamellar domains which differ in
  composition, aggregation status and fusion
  temperatures
• The main goal of any topic formulation for the
  delivery of active substances through the skin is
  enhancing diffusion of hydrophilic and lipophylic
  substances through the mosaic structured lipids
  domains of the horny layer
• One of the most effective strategy consists of
  uniforming corneal lipidc phase with substances
  capable to enhance fluidity of lipidic bilayer so
  improving solubility og lipophilic compounds
• Another important pathway is to induce, in a
  transitory way, the formation of aqueous channels
  (hydropores) capable to allow aspecific passage
  of hydrophiliic molecules even with high
  molecular weight

3
COMBINED STRATEGY OF DRUG DELIVERY SYSTEM
MATRIPOR PLUS

• MATRIPOR PlusTM is a device based on innovative
  technology capable to induce aqueous hydropores
  inside epidermal layer
• By mean of a particular discontinous electrical
  stream generator is capable to generate an
  elastic pulsated wave with low frequency of which
  operator can modulate intensity in function of
  clinical or aesthetic indications
• MATRIPOR PlusTM is based on sinergy of these
  following technologies
• Iontophoresys
• Cavitation
• Electroporation
• Electrorepulsion

4
ELECROPORATIVE GELS

• Electroporative gels are especially formulated to
  improve MATRIPOR Plus effectivness they are
  based on cellulose derivative hydrosoluble
  gelifing polymer with no charged functional
  groups to avoid any interaction with the active
  molecules ionization
• In every gel the most effective penetration
  enhancement available to enhance the diffusion
  rate of the molecules delivered with MATRIPOR
  Plus(INCI Ethoxydiglycole, Propylen glycole)
• In every gel only high and recognized
  effectiveness active molecules with low molecular
  weight have been introduced (low O/W partitiolal
  coefficient) and with one or more chargable
  groups
• No vegetables extracts have been employed for the
  impossibility to foresee the penetration rate
  through the skin
• Every gel has a very high safety profile that
  permit its usage for a deep absorption

5

• CELLULITIS AND LOCALIZED ADIPOSITIES
• GEL 01
• (Aescin, Pure Anydrous Caffein, Carnitine)
• Lipolytic action
• Diuretic action
• Anti-fibrotic action
• Venotropic action
• WAY OF APPLICATION
• Apply with trans-dermal electro-vehiculation
  devices.
• It is suggestible to perform a preliminary
  cheratolysis with specific cavitation device
  and EXFOLIATING GEL both enclosed with MATRIPOR
  Plus

6
MUSCLE TROPHISM GEL 02 (CARNOSINE, CARNITINE,
LYSINE, ARGININE, INOSITOL) -PH
Buffering -Pro-energetic function for muscular
fibbers -Improving of arterial perfusion of the
muscles WAY OF APPLICATION Apply with
trans-dermal electro-vehiculation devices. It is
suggestible to perform a preliminary cheratolysis
with specific cavitation device and EXFOLIATING
GEL both enclosed with MATRIPOR Plus
7

• DEEP MOISTURIZING
• GEL 03
• (PCA, Hyaluronic acid, Arginine, Glucosamine,
  Serine, Arginine, Tocopherol, Allantoin)
• Umectant action
• TEWL lowering
• Skin surface NMF restoring
• Cheratoplastic action
• Lenitive and nourishing actions
• WAY OF APPLICATION
• Apply with trans-dermal electro-vehiculation
  devices.
• It is suggestible to perform a preliminary
  cheratolysis with specific cavitation device
  and EXFOLIATING GEL both enclosed with MATRIPOR
  Plus

8
ATONIC SKIN - ANTI-AGE GEL 04 ElastocellTM
(Skin renovation bio-complex), Carnosine,
Glutathione, Glycolic Acid -Epidermal turn-over
promoter -Fibroblasts booster -Detoxifying and
bleaching action WAY OF APPLICATION Apply with
trans-dermal electro-vehiculation devices. It is
suggestible to perform a preliminary cheratolysis
with specific cavitation device and EXFOLIATING
GEL both enclosed with MATRIPOR Plus
9
COUPEROSE E SMALL VEINS TROPHYSM GEL
05 (VITAMINE K1, PURE RUTIN, ARGININE, VITAMINE
PP) -Vascular desensitizing action -Lenitive
and red skin calming action -Capillary-tonic
action WAY OF APPLICATION Apply with
trans-dermal electro-vehiculation devices. It is
suggestible to perform a preliminary cheratolysis
with specific cavitation device and EXFOLIATING
GEL both enclosed with MATRIPOR Plus
10
SKIN PIGMENTATIONS GEL 06 AZELOGLYCINETM
(Azelaic acid hydro soluble form) GLUTATHION,
KOJICO ACID -Tyrosinase inhibition synergistic
activity - eu/feomelanic biochemical synthesis
switch WAY OF APPLICATION Apply with
trans-dermal electro-vehiculation devices. It is
suggestible to perform a preliminary keratolysis
with specific cavitation device and EXFOLIATING
GEL both enclosed with MATRIPOR Plus
11
EXPRESSION FINE LINES GEL 07 ARGIRELINETM,
HYALURONIC ACID, GLYCOLIC ACID, HUMECTANT AGENTS
(NMF) --Film former and re-hydrating -Superfic
ial filling of expression fine lines -Superficial
muscle relaxation (Botulinum effect) WAY OF
APPLICATION Apply with trans-dermal
electro-vehiculation devices. It is suggestible
to perform a preliminary cheratolysis with
specific cavitation device and EXFOLIATING GEL
both enclosed with MATRIPOR Plus
12
FILLER BOOSTING GEL GEL 08 (GLUCOSAMINE,
CONDROITIN SULPHATE, CARNOSINE,
ECHINACOSIDE) -Inhibitory activity on dermal
hyaluronidases -Dermal renovation
stimulus -Dermal elastases inhibition -GAG
bio-synthesis stimulus WAY OF
APPLICATION Apply with trans-dermal
electro-vehiculation devices. It is suggestible
to perform a preliminary cheratolysis with
specific cavitation device and EXFOLIATING GEL
enclosed with MATRIPOR Plus
13
EXFOLIATING GEL GEL 09 (GLYCOLIC ACID, LACTIC
ACID, ELASTOCELLTM) -Horny layer softening and
thickening action -Horny layer turn-over
action -Exfoliating action WAY OF
APPLICATION Apply a small amount of gel on the
skin area to treat before every MATRIPOR Plus
session to improve the active compounds deep
diffusion and absorption.
14
PHOSPHATIDYLCHOLINE GEL GEL 10 (PHOSPHATIDYLCHOLIN
E 2, POLYSORBATE 20) -Lipolitic and fatty
tissue remodelling WAY OF APPLICATION Apply
with trans-dermal electro-vehiculation
devices. It is suggestible to perform a
preliminary cheratolysis with specific
cavitation device and EXFOLIATING GEL both
enclosed with MATRIPOR Plus