Michael Weinrich, M'D'

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• Michael Weinrich, M.D.

Interim Report to Council NCMRR Jan 2008
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Grant Funding
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Research Directions

• Translational Research
• Basic Research to Advance Rehabilitation
• Plasticity and Adaptation of Tissue in Response
  to Activity and Environment
• Reintegration of Persons with Disabilities into
  the Community

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Cross Cutting Objectives

• Develop mechanisms to support new investigators
• Enhance consumer input and outreach
• Extend the interdisciplinary model from basic
  research through applied research and community
  studies

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Translational Research
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Advanced Prosthetics
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Basic Research
Science. 2007 Jul 20317(5836)381-4. Epub 2007
Jul 5. Links Mosaic organization of neural stem
cells in the adult brain. Merkle FT, Mirzadeh Z,
Alvarez-Buylla A. Department of Neurosurgery and
Developmental and Stem Cell Biology Program,
University of California, San Francisco, San
Francisco, CA 94143-0525, USA. The in vivo
potential of neural stem cells in the postnatal
mouse brain is not known, but because they
produce many different types of neurons, they
must be either very versatile or very diverse. By
specifically targeting stem cells and following
their progeny in vivo, we showed that postnatal
stem cells in different regions produce different
types of neurons, even when heterotopically
grafted or grown in culture. This suggests that
rather than being plastic and homogeneous, neural
stem cells are a restricted and diverse
population of progenitors.
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Plasticity
Effect of Constraint-Induced Movement Therapy on
Upper Extremity Function 3 to 9 Months After
Stroke The EXCITE Randomized Clinical Trial
Steven L. Wolf, PhD, PT Carolee J. Winstein,
PhD, PT J. Philip Miller, AB Edward Taub, PhD
Gitendra Uswatte, PhD David Morris, PhD, PT
Carol Giuliani, PhD, PT Kathye E. Light, PhD,
PT Deborah Nichols-Larsen, PhD, PT for the
EXCITE Investigators JAMA. 20062962095-2104.
ABSTRACT Context  Single-site studies suggest
that a 2-week program of constraint-induced
movement therapy (CIMT) for patients more than 1
year after stroke who maintain some hand and
wrist movement can improve upper extremity
function that persists for at least 1 year.
Objective  To compare the effects of a 2-week
multisite program of CIMT vs usual and customary
care on improvement in upper extremity function
among patients who had a first stroke within the
previous 3 to 9 months. Design and Setting  The
Extremity Constraint Induced Therapy Evaluation
(EXCITE) trial, a prospective, single-blind,
randomized, multisite clinical trial conducted at
7 US academic institutions between January 2001
and January 2003.
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Reintegration of Persons with Disabilities into
the Community

• This is really hard
• Stay tuned

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New Mechanisms for Young Investigators

• Extended pay lines for R03, R21
• Extended pay line for R01
• K99-R00 award
• 25/301 FY06 27/305 FY07
• (New/Total Investigators)
• New K12s
• ERRIS grant writing workshop
• NCMRR biannual training meeting
• NCMRR Medical Rehabilitation Infrastructure
  Centers

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Enhance Consumer Input and Outreach

• Encouraged investigators to document progress
  reportsmarginally successful
• Discussed with NCMRR Advisory Board
• Opened discussions with NIH OD re SBIR

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Extend Interdisciplinary Model

• PAR04-077 3 years lt 70 applications
• 6 funded
• Problem investigators identified good problems,
  formed interdisciplinary teams and then did not
  use them to write the R01 applications
• Solution Reissue to support 2 year
  conference/planning grant applications