EDEN Integrated Project proposal

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EDEN Integrated Project proposal Emerging
Diseases in a changing European Environment
Florence Putterman
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The European Union is expanding to incorporate
states with significantly different working
environments, agricultural practices and human
and animal disease profiles. At the same time,
the earth's climate is in a warming phase, a part
of which may be due to human activities. Some
models suggest that this phase will continue,
with effects that will be especially pronounced
in temperate regions. Both local and global
changes may independently or in combination have
an impact on human/animal health, by favouring
the spread of diseases already found in Europe,
or the re-emergence of diseases long dormant
here.

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Predicting the next emerging or re-emerging
disease is virtually impossible, but we can and
should prepare now both the methods for
monitoring the changing epidemiological
landscapes of Europe and the tools that must be
brought into action quickly once new diseases
appear. Of all the diseases potentially in this
grouping, it is expected that those involving
intermediate hosts, insects, ticks or other
vectors, will be the most important.
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EDEN call
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FP6 call The aim is to identify, evaluate and
catalogue European ecosystems and environmental
conditions linked to global change, which can
influence the spatial and temporal distribution
and dynamics of pathogenic agents. A coordinated
European approach is needed to provide predictive
emergence and spread models including global and
regional prevention, early warning, surveillance,
and monitoring tools and scenarios. Coordination
with international organizations and third world
countries is essential.
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Keywords
Coordinated European approach
The aim is to identify, evaluate andcatalogue
European ecosystems andenvironmental
conditions linked to global change and which can
influence the spatial distribution the temporal
distribution and the dynamics of pathogenic
agents.

• Predictive emergeance and spread models including
  the following tools and scenarios
• Global and Regional prevention
• Early warning
• Surveillance
• Monitoring

Coordination with international organisations and
third world countries.
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EDEN project
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Indentify a set of Indicator diseases
Tick-borne Diseases diseases already present
in Europe that have shown significant recent
increases in incidence, at least partly due to
changes in human behaviour in relation to the
environment.
Rodent-borne Viruses (hanta, arena, cowpox)
widespread but under-reported diseases within
Europe, with strong links with habitat and
landscape structures.
Leishmaniasis persistent on the southern
fringes of Europe and beyond (southern
Mediterranean basin), with the potential to
expand as environments change.
West Nile Virus periodic and occasionally
severe local outbreaks, especially on the eastern
fringes of Europe, currently showing strong
associations with landscape patterns.
Malaria an ancient scourge of Europe, currently
now on her southern and eastern fringes, with the
potential for re-emergence following
environmental changes.
Africa Plateform new strains of West Nile Virus
and new diseases such as Rift Valley Fever may be
introduced to Europe from tropical regions linked
by bird and other (e.g. traded livestock)
migratory routes to Europe.
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Study diseases using a common appraoch
WP / Tasks Patterns Processes
Landscape, Biotopes and Habitats Description of the environmental components and habitats Monitoring of major environmental events and their consequences on the cycles components
Vector Bionomics and Competence Inventory, vectorial capacity and competence of vector populations Monitoring introduction, establishment and spread of vectors
Public Health and Human Activities Public health demography of the human populations at risk Monitoring of significant population flows between and in countries
Animal reservoirs Epidemiological inventory of the receptive wild and domestic animal populations Monitoring migrations (avifauna), movements and transport (livestock) of the animal reservoirs
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EDEN work packages
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Vertical Sub-Projects (SP)
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and Horizontal Integration Teams (HIT)
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Ecosystem components studies
WP1 Landscape, habitat, climate
West Nile
Malaria
Tick borne
Rodent borne
Leishmania
Africa Platform
WP2 Vector
Pattern
Process
WP3 Public Health
Pattern
Process
WP4 Animal Reservoir
Pattern
Process
WP5 Individual disease Data management
Modelling
Pattern
Process
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Ecosystem components studies
Horizontal integration
WP1 Landscape, habitat, climate
West Nile
Malaria
Tick borne
Rodent borne
Leishmania
Africa Platform
WP2 Vector
WP6 Horizontal activities
Pattern
Process
WP3 Public Health
WP6.1 Data management
Pattern
Process
WP4 Animal Reservoir
WP6.2 RS tools
Pattern
Process
WP5 Individual disease Data management
Modelling
WP6.3 PhD program
Pattern
Process
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Ecosystem components studies
Emergence spread models
Horizontal integration
WP1 Landscape, habitat, climate
West Nile
Malaria
Tick borne
Rodent borne
Leishmania
Africa Platform
WP2 Vector
WP6 Horizontal activities
Pattern
Process
WP3 Public Health
WP6.1 Data management
WP7 Overall Integration Tools scenarios
Pattern
Process
WP4 Animal Reservoir
WP6.2 RS tools
Pattern
Process
WP5 Individual disease Data management
Modelling
WP6.3 PhD program
Pattern
Process
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Ecosystem components studies
Emergence spread models
Horizontal integration
WP1 Landscape, habitat, climate
West Nile
Malaria
Tick borne
Rodent borne
Leishmania
Africa Platform
WP2 Vector
WP6 Horizontal activities
Pattern
Process
WP3 Public Health
WP6.1 Data management
WP7 Overall Integration Tools scenarios
Pattern
Process
WP4 Animal Reservoir
WP8 Training, Dissemination, Management
Coordination
WP6.2 RS tools
Pattern
Process
WP5 Individual disease Data management
Modelling
WP6.3 PhD program
Pattern
Process
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EDEN strategy
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HEALTH/ENVIRONMENT RESEARCH of model diseases in
a variety of representative environmental settings
TOOLS and POLICIES
Characterise (new) transmission cycles
Catalogue of ecosystems and environmental
conditions at risk emerging disease hot-spots
Identify factors triggering emergence and spread
Develop predictive emergence and spread models
Develop early warning, surveillance and
monitoring tools
Identify environmental changes likely to favour
emergence
Contribute to decision support and policy making
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HEALTH/ENVIRONMENT RESEARCH of model diseases in
a variety of representative environmental settings
TOOLS and POLICIES
Characterise (new) transmission cycles
Catalogue of ecosystems and environmental
conditions at risk emerging disease hot-spots
EDEN strategy document integrated
trans-disciplinary health/environment approach.
Identify factors triggering emergence and spread
Develop predictive emergence and spread models
Develop early warning, surveillance and
monitoring tools
Identify environmental changes likely to favour
emergence
Contribute to decision support and policy making
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EDEN strategy document
A key deiverable produced by the Steering
Committee with back-up from the advisory group,
specialists with internationally recognised
skills in (i) biodiversity monitoring and
assessment, (ii) environmental change detection,
(iii) disease modelling, remote sensing, image
processing and interpretation, and (iv) public
health. The EDEN strategy document will propose
an innovative integrated trans-disciplinary
health/environment approach for the unified
analysis of the various EDEN outputs. The
development of such an approach will be a major
breakthrough of EDEN.
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Objectives timeframe
SD
HE
TP
Dissemination
SD EDEN Strategy document HE
Health/Environment research TP Tools and
policies
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External sources
EDEN Indicator Diseases
Individual diseases models
EDEN Steering Committee
Advisory group
integrated models health-environment
Knowledge Flow
DMEWS Disease Monitoring Early Warning Systems
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Conclusion
Annex1, chap 4.1 Contribution to the objectives
of the sub-priority EDENs bold ambition is to
enable a multi-DMEWS system on a solid scientific
foundation running from the theoretical
understanding of the reasons for the emergence of
new diseases in vulnerable ecosystems, through an
understanding of complex disease dynamics, to the
practical application of such knowledge to
disease control. We do not know the precise
shape of this future yet EDEN presents a chance
to Europe to invest in some of the brightest and
best researchers to ensure success with this
vision, and in doing so to advance significantly
the state-of-the-art and put Europe firmly at the
forefront of DMEWS.
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EDEN management
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Project OfficerT. Karjalainen
ADVISORY GROUPScientists, Users
PROJECT MANAGEMENT TEAM Financial Advisor Admin
Assistant CIRAD support team
EDEN CoordinatorEU Focal PointR. Lancelot -
CIRAD
SCIENTIFIC ADVICE
STEERING COMMITTEE
Chairman SCD.J. Rogers
Secretary SCG. Hendrickx
Members Steering Committee Vertical
Sub-projects EDEN-TBD S. Randolph
(UK) EDEN-Robo H. Henttonen (Fin) EDEN-LEI P.
Ready (UK) EDEN-WNV P. Reiter (Fr) EDEN-MAL D.
Fontenille (Fr) EDEN-AFR Y. Thiongane
(Sn) Horizontal Integration Teams Env. Changes
E. Lambin (Be) LRes. Mod D. J. Rogers (UK) Data
Mngt W. Wint (UK) D. Modelling H. Heesterbeek
(Nd) Biodiv JF. Guégan (Fr)
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EDEN Central managementDay to Day
EDEN Coordinator Integration Renaud Lancelot
Secretariat FinancialOlivier Pierre Administrat
ive Sylvie Pugin CIRADTechnical inputs
Chairman SCScientific coordination David Rogers
Secretary SC Operational Guy Hendrickx
Solving EDENs problems
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EDEN - Deputy SP Coordinators
TBD Kurt Pfister Ludwig-Maximilians University Munich, Germany (LMU)
TBD Milan Labuda Slovak Academy of Sciences - Bratislava, Slovakia (SAS)
Robo Herwig Leirs University of Antwerp Antwerp, Belgium (UA)
LEI Montserrat Gallego University of Barcelona - Barcelona, Spain (UB)
LEI Robert Farkas Szent István University - Budapest, Hungary (SZIE)
WNV Zdenek Hubalek Academy of Sciences of the Czech Republic Brno, Czech Republik (IVB)
WNV Alessandra della Torre University of Rome La Sapienza - Rome, Italy (UNISAP)
MAL Rajae El Aouad National Institute of Hygiene - Rabat, Morocco (INH)
MAL Gabriella Nicolescu National Institute of Research and Development for Microbiology and Immunology Cantacuzino Bucharest, Romania (NIRDMI)
AFR Ouaffa Fassi Fihri Agro-veterinary Institute Rabat, Morocco (IAV)
AFR Jean-François Molez Institut de Recherche pour le Développement Dakar, Sénégal (IRD)
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EDEN - Focal points
Topic Person Affiliation
Gender equality and personnel interaction Sarah Randolph University of Oxford, Oxford, UK
Ethical aspects and safety rules of laboratory work Kurt Pfister Ludwig-Maximilians University, Munich, Germany
Ethical aspects of working with live animals Heikki Henttonen Finnish Forest Research Institute, Vantaa, Finland
Gender action plan
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EDEN Advisory Group
Duane Gubler Asia-Pacific Institute of Tropical Medicine and Infectious Diseases, John A. Burns School of Medicine, Hawaii, USA
Santiago Mas Coma President of the European Federation of Parasitologists (EFP), University of Valencia, Valencia, Spain
Rainer Sauerborn Medical Director of the Department of Tropical Hygiene and Public Health of the University of Heidelberg, Germany
Graham White Mosquito Fly Research Unit, Center for Medical, Agricultural Veterinary Entomology, Gainesville, Florida, USA
Philippe Martin Principal Administrator, European Commission, Directorate-General for Health and Consumer Protection, Risk Assessment (DG-SANCO)
Bettina Menne Senior officer, Global Change and Health Program, World Health Organisation of the United Nations (WHO), Rome, Italy
Jan Slingenbergh Senior officer, Insect Pest Management, Food and Agriculture Organisation of the United Nations (FAO), Rome, Italy
Antonio Petrini Animal Health Information Department, World Organisation for Animal Health (OIE), Paris, France
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