Diapositiva 1

1
Legenda della tabella 95CIIntevalli di
confidenza al 95 percentile, CABGBypass
aorto-coronarico, HRHazard Ratio
PLATO PLATO-PCI PLATO PLATO-PCI PLATO PLATO-PCI PLATO PLATO-PCI PLATO PLATO-PCI PLATO PLATO-PCI PLATO PLATO-PCI PLATO PLATO-PCI PLATO PLATO-PCI
Endpoint Ticagrelor Clopidogrel HR (95 CI) P Ticagrelor Clopidogrel HR (95 CI) P
Composito di morte vascolare, Reinfarto e Stroke 864/9333 (9.8) 1014/9291 (11.7) 0.84 (0.77-0.92) lt0.001 569/6732 (9.0) 668/6676 (10.7) 0.84 (0.75-0.94) 0.0025
Morte vascolare 353/9333 (4.0) 442/9291 (5.1) 0.79 (0.69-0.91) lt0.001 221/6732 (3.4) 269/6676 (4.3) 0.82 (0.68-0.98) 0.0250
Morte totale 399/9333 (4.5) 506/9291 (5.9) 0.78 (0.69-0.89) lt0.001 252/6732 (3.9) 311/6676 (5.0) 0.81 (0.68-0.95) 0.0103
Reinfarto 504/9333 (5.8) 593/9291 (6.9) 0.84 (0.75-0.95) 0.005 328/6732 (5.3) 406/6676 (6.6) 0.80 (0.69-0.92) 0.0023
Stroke 125/9333 (1.5) 106/9291 (1.3) 1.17 (0.91-1.52) 0.22 75/6732 (1.2) 69/6676 (1.1) 1.08 (0.78-1.50) 0.6460
Ischemico 96/9333 (1.1) 91/9291 (1.1) 0.74 59/6732 (0.9) 59/6676 (0.9) 1.0000
Emorragico 23/9333 (0.2) 13/9291 (0.1) 0.10 12/6732 (0.2) 9/6676 (0.1) 0.6634
Causa sconosciuta 10/9333 (0.1) 2/9291 (0.02) 0.04 5/6732 (0.07) 1/6676 (0.01) 0.2187

Trombosi di stent
Definita 62/4949 (1.3) 97/4928 (2.0) 0.64 (0.46-0.88) 0.0054
Probabile o definita 104/4949 (2.2) 142/4928 (3.0) 0.73 (0.57-0.94) 0.0142
Possibile, probabile o definita 132/4949 (2.8) 179/4928 (3.8) 0.73 (0.59-0.92) 0.0068

Sanguinamenti maggiori 961/9235 (11.6) 929/9186 (11.2) 1.04 (0.95-1.13) 0.43 689/6651 (11.5) 691/6585 (11.6) 0.99 (0.89-1.10) 0.8803
CABG-associati 619/9235 (7.4) 654/9286 (7.9) 0.95 (0.85-1.06) 0.32 430/6651 (7.1) 480/6585 (8.0) 0.89 (0.78-1.01) 0.0745
Non CABG-associati 362/9235 (4.5) 306/9186 (3.8) 1.19 (1.02-1.38) 0.03 272/6651 (4.7) 235/6585 (4.0) 1.16 (0.97-1.38) 0.1040
Necessità di trasfusione 818/9235 (8.9) 809/9186 (8.9) 1.00 (0.91-1.11) 0.96 531/6651 (8.9) 525/6585 (8.7) 1.01 (0.89-1.14) 0.9095
Emorragie intracraniche 26/9235 (0.3) 14/9186 (0.2) 1.87 (0.98-3.58 0.06 15/6651 (0.3) 11/6585 (0.2) 1.36 (0.63-2.97) 0.4364
Fatali 11/9235 (0.1) 1/9186 (0.01) 0.02
Non-fatali 15/9235 (0.2) 13/9186 (0.2) 0.69