Kein Folientitel

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Saratin - mechanism of action
vWF
Platelet
Biomedical RD
Folie (slide) 1
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Saratin - mechanism of action
vWF
Platelet
Biomedical RD
Folie (slide) 2
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Saratin - mechanism of action
vWF
Platelet
Biomedical RD
Folie (slide) 3
4
Saratin - mechanism of action
vWF
Platelet
Biomedical RD
Folie (slide) 4
5
Saratin - mechanism of action
vWF
Platelet
Biomedical RD
Folie (slide) 5
6
Saratin - mechanism of action
vWF
Platelet
Biomedical RD
Folie (slide) 6
7
Saratin - mechanism of action
vWF
Platelet
Biomedical RD
Folie (slide) 7
8
Saratin - mechanism of action
Platelet
Biomedical RD
Folie (slide) 8
9
Saratin - mechanism of action
Biomedical RD
Folie (slide) 9
10
Saratin - mechanism of action
Biomedical RD
Folie (slide) 10
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 11
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 12
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 13
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 14
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 15
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 16
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 17
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 18
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 19
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 20
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 21
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 22
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Saratin - mechanism of action
Vessel wall injury exposes collagen to elements
of flowing blood.
Biomedical RD
Folie (slide) 23
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 24
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 25
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 26
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 27
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 28
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Saratin - mechanism of action
vWF A3 domain binds to collagen.
Biomedical RD
Folie (slide) 29
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 30
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 31
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Saratin - mechanism of action
vWF A1 domain targets GP Ib/IX/V receptor of
circulating platelets, tethering them to the
vessel wall.
Biomedical RD
Folie (slide) 32
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 33
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 34
35
Saratin - mechanism of action
Direct collagen-platelet interactions (GP Ia/IIa,
GP VI etc.) anchor and then lead to activation of
the tethered platelet.
Biomedical RD
Folie (slide) 35
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 36
37
Saratin - mechanism of action
Biomedical RD
Folie (slide) 37
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 38
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 39
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 40
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 41
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 42
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 43
44
Saratin - mechanism of action
Occlusive thrombus!
Biomedical RD
Folie (slide) 44
45
Saratin - mechanism of action
How does saratin interfere with arterial
thrombosis?
Biomedical RD
Folie (slide) 45
46
Saratin - mechanism of action
Biomedical RD
Folie (slide) 46
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 47
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 48
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 49
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Saratin - mechanism of action
Biomedical RD
Folie (slide) 50
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Saratin - mechanism of action
S
Biomedical RD
Folie (slide) 51
52
Saratin - mechanism of action
S
S
Biomedical RD
Folie (slide) 52
53
Saratin - mechanism of action
S
S
S
Biomedical RD
Folie (slide) 53
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Saratin - mechanism of action
S
S
S
S
Saratin binds to collagen, preventing interaction
with vWF and hence platelets.
Biomedical RD
Folie (slide) 54
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Saratin - mechanism of action
S
S
S
S
Biomedical RD
Folie (slide) 55
56
Saratin - mechanism of action
S
S
S
S
Biomedical RD
Folie (slide) 56
57
Saratin - mechanism of action
S
S
S
S
Biomedical RD
Folie (slide) 57
58
Saratin - mechanism of action
S
S
S
S
Biomedical RD
Folie (slide) 58
59
Saratin - mechanism of action
S
S
S
S
Biomedical RD
Folie (slide) 59
60
Saratin - mechanism of action
S
S
S
S
Biomedical RD
Folie (slide) 60
61
Saratin - mechanism of action
S
S
S
S
Biomedical RD
Folie (slide) 61
62
Saratin - mechanism of action
S
S
S
S
Biomedical RD
Folie (slide) 62
63
Saratin - mechanism of action
S
S
S
S
Saratin acts as a molecular plaster, neutralising
platelets BEFORE they adhere and become activated.
Biomedical RD
Folie (slide) 63