Presentaci

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ARGIRELINE INCI name Acetyl Hexapeptide-3 What
is Argireline? Argireline, is the active
ingredient in Bio Jouvance Paris Botu-Like, it is
safe, non-toxic, topical alternative to Botox
(Botulinum toxin type A), and has been
scientifically proven effective in reducing
wrinkles and preventing the formation of new
lines in a safe and natural manner.
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ARGIRELINE origin

• ARGIRELINE
• The discovery of this hexapeptide (six naturally
  occuring amino acids in combination) was an
  exciting find, as Argireline has proven to
  inhibit two internal processes that strongly
  contribute to the formation of wrinkles .

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• ARGIRELINE how does it work?
• The SNARE complex, a natural formation of
  proteins in aging skin that stimulates
  neurotransmitters, provoking facial muscle
  contractions, thereby causing wrinkles and lines.
• 2. The overproduction and release of
  catecholamine-hormones, such as adrenaline, which
  affect the sympathetic nervous system and cause
  wrinkles through repetitive facial movements.

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By inhibiting both the SNARE complex and
overproduction of catecholamine, skin smoothes
out. Testing was performed using an oil/water
emulsion containing 5 Argireline . Subjects
experienced nearly a 30 reduction in the
appearance of wrinkles after Just 30 days of
use.
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The most striking improvement noted when using
Argireline is the forehead and the eye area where
most crows feet and deep lines are located. The
method by which Argireline works, and the
relaxation of the facial muscles produced by
topical application of Argireline, is similar to
that of botulinum toxin type A, but without the
frightening potential side effects of this
toxin and without paralyzing the muscles.
Instead, with continued use Argireline
Reduces the intensity and frequency of
neurotransmitters that cause muscle
contractions
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Assists in preventing the appearance of fine
lines caused by smiling, frowning, etc., with no
disruption in natural expression (smile as wide
as you want!) Relaxes facial
muscles Smoothes out and minimizes depth of
lines
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ARGIRELINE

• Bio Jouvance Paris Botu-Like contains the
  highest quality and potency of Argireline
  available.
• Professional products
• contain15Argireline.
• Retail products contain
• 10 Argireline

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ARGIRELINE how does it work?
Modulation of SNARE complex formation by peptides
analogous to SNAP-25
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ARGIRELINE how does it work?

• Another important cause of wrinkle formation is
  the excessive secretion of catecholamines, such
  as adrenalin and noradrenalin.
• ARGIRELINE also modulates this overproduction.

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ARGIRELINE how does it work?
Modulation of catecholamine secretion
Partial secretion blocking
Synaptic distance increase
Reversible in 6 months
Normal synapse
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ARGIRELINE how does it work?
Modulation of catecholamine secretion
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ARGIRELINA The Effects
Wrinkle Reduction Test
ARGIRELINA reduces the deep lines by 27 in 30
days
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How to use Bio Jouvance Paris Botu-like in Salon
treatment You can include this unique treatment
with any other treatments that you are already
offering. Botu-Like is a wonderful treatment to
offer as a post microdermabrasion
treatment. Although clients will see immediate
result even with one treatment, a series of 6
treatments is suggested for longer lasting
results on a weekly basis. Home care products can
be used on a daily basis to eliminate wrinkle
formation during and after the series of
treatments.


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FAQ How much salon should charge for Bio Jouvance
Paris Botu-like treatment? Most salons charge
about 120 to 150 per treatment. What is the
cost of Botu-like treatment to salon? Botu-Like
professional products come in package of 10
individual applications for the price of 190,
therefore each treatment costs 19. Botu-Like
home care products are available in 1oz jars.
Retail price 72 Who should not use Bio Jouvance
Paris Botu-Like Botu-Like has been tested to be
safe for use on all skin types.
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BOTU-LIKE ANTI-AGING TREATMENT Step-by-Step
for Professionals PRODUCTS REQUIRED Bio
Jouvance Cleanser (Rejuvenating/ Hydrating/
Clarifying) Bio Jouvance Toner (Rejuvenating/
Hydrating/ Clarifying) BJ-940-P Gentle Face
Body Polish BJ-870-P Octopeel Enzyme Peeling
Mask BJ-890-P Botu-Like Ampoule EURO
1512 Portable Ultrasound BJ-620-P Cellular
Mask BJ-615-P Rejuvenating Night
Cream BJ-610-P Rejuvenating Day Cream
BJ-845-P 4-in-1 Lumines Cream LENGTH OF
TREATMENT 90 MINUTES
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• DIRECTIONS FOR USE
• Cleanse the face with a suitable facial cleanser
  for the clients skin type and condition.
• Apply appropriate toner on clients face after
  toning the skin, make sure the skin is completely
  dry.
• Exfoliate the facial skin. First, use the Gentle
  Face Body Polish by scrubbing the skin lightly.
  
• Exfoliate the skin further with Bio Jouvance
  enzyme activated Octopeel(see package for
  instructions).
• Perform comedone extractions on the skin.
  Sanitize the skin using the High Frequency after
  extractions.
• Wear latex gloves to protect product
  contamination. Open one Botu-Like ampoule
  according to instructions in the package. Use a
  syringe to extract the Botu-Like from the vial.
  Analyze the clients face to detect the deepest
  wrinkles. Using the tip of the syringe, apply a
  little amount of Botu-Like at a time on the
  wrinkles, covering all the lines and wrinkles
  with the product. Using the tip of the syringe
  against the skin massage the Botu-Like into the
  wrinkles and lines with circular and upward
  motion.
• Cut small and thin pieces of Collagen sheet
  enough to cover only the treated areas. Use your
  fingertips and a little pressure to stabilize the
  strips on the lines and wrinkles.

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• Use Ultrasound machine over the treated area to
  help breakdown Botu-Like into macromolecules, for
  a better penetration of its active ingredients.
  The ultrasound machine should be used directly
  over the strips and treated area, then all over
  the face.
• If performing a full facial, use a moderate
  amount of Bio Jouvance Oxygenating Face and Body
  Massage Oil on the clients face and perform your
  massage.
• Apply a thin layer of Bio Jouvance Cellular Mask
  over the entire face, neck and décolleté area
• Finally complete the facial treatment by applying
  the appropriate day or night cream.
• Apply Bio Jouvance 4-in-1 Lumines Cream SPF30
  during daytime.
• Massage cold Beauty Globes, by rolling it over on
  the treated area, then all over the face.
• A series of 6 treatments, for one treatment per
  week is suggested for maximum results. Client
  should use home treatment daily for 30 days.
• To achieve optimum results, it is recommended to
  advice clients to use Bio Jouvance take home
  daily beauty
• regimen products and use for at least a month.

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For More Information and to visit the salon near
you offering BOTU-LIKE treatment, please call
1-800-272-1716 Or visit our web site
www.biojouvance.com
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ARGIRELINA sus efectos
Ensayo de disminución de las arrugas
CREMA PLACEBO
CREMA ARGIRELINA
Day 1
Day 15
Day30
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ARGIRELINAThe Effects
Wrinkle reduction test
Day 30
Day 1
Day15
Topographic image of the dermis taken by laser
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Application of Botu like for professional use.
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ARGIRELINE Clinical Safety Data
ARGIRELINE During various clinical
tests Argireline has been proven to be 100 safe
from toxins.
ARGIRELINE No irritation or edema was
reported after serveral months of
constant use.