Ppara PowerPoint PPT Presentations

PPARa activators lower small dense LDL. Plasma triglyceride and cholesterol levels ... Allele frequencies for SNP 3 according. to plasma triglyceride levels ...

CLA-1 expression is regulated by PPARa activators. in differentiated human macrophages. PPARa activators induce cholesterol efflux. and reverse cholesterol transport ...

Center for Molecular Toxicology and Carcinogenesis, ... is evidence that activation of PPARb/d can either potentiate or attenuate cancer. ...

The biology of peroxisomes and their effect on skin biology and diseases development

The biology of peroxisomes and their effect on skin physiology and pathology

Enhancing progenitor cell self-renewal: a new approach to stimulating red cell production Development of novel therapies for Diamond-Blackfan anemia and other ...

2-methyl-2-phenoxy-propionic acid (HepagenTM - Fatro) is the only PPAR-alpha activator available in veterinary medicine. 2-methyl-2-phenoxy-propionic acid by binding to PPAR-alpha up-regulates the transcription of several genes involved in lipid and glucose metabolism. As a result it promotes the activation of mitochondrial and peroxisomal beta-oxidation pathways and liver gluconeogenesis. Enhanced lipid oxidation brings to the reduction of triglyceride accumulation in hepatocytes, recovery of liver functions and increased energy availability for glucose production. Direct up-regulation of genes involved in gluconeogenesis intensifies hepatic glucose output and restores energy balance. The anti-inflammatory properties of this PPAR agonist further help cows, considering that inflammatory conditions play a role in the pathogenesis of fatty liver and many other diseases.

Role of the liver in the regulation of energy homeostasis ... gluconeogenesis - sterol metabolism - heme synthesis - amino acid. metabolism ...

Effects independent of the degree of glycemic control (HbA1c) ... internal elastic lamina. Gizard et al. JCI 2005;115(11) :3228-3238. transcription -1 ...

Title: L-410198: Go/No-Go to Phase III and Dose Selection (I) Subject: L-410198 Author: Merck Last modified by: Eva Maria Gramatt Created Date: 4/1/2002 8:17:10 PM

DNA structure. Structure of Cells. Plasma membrane. Cytoplasm. Nucleus ... Keeps the DNA molecules of eukaryotic cells separate from metabolic machinery of ...

The Regulation of Eukaryotic Gene Expression..using the example of PEPCK PEPCK This is an acronym for an enzyme PhosphoEnol Pyruvate CarboxyKinase This enzyme is ONLY ...

Most patients with atherogenic dyslipidaemia are insulin resistant ... Randomised dietary clinical trials of polyunsaturated fats versus. saturated fats ...

Control of Metabolic Diseases in Dairy Cows Roberto Farina DVM Fatro Group High incidence of Metabolic Diseases Metabolism All the chemical and physical changes ...

Diabetologie: Was ist neu seit 2005? https://www2.univadis.de/academia/?section=symposien&study=symp00022

The one shown here, from PDB entry 1i6h, is from yeast cells. ... enzyme gets started, RNA polymerase marches confidently along the DNA copying ...

problem tica de la investigacion vision puntos criticos bioeficacia bioestadistia econometria conocimientos & tecnologia nutricion de precision

... function of visceral fat. Future research ... Visceral Fat Associates with ... Some Patients have Predominant Visceral Fat. Obesity Is An ...

Genetics of Type 2 Diabetes

http://creativecommons.org/licenses/by-sa/2.0/ * * * * * * Decreased glucose tolerance Muscle insulin resistence b Cell compensation Increased gluconeogenesis in ...

Patient A showed iron accumulation in the substantia nigra and striatum on T2-weighted image of MRI ... Chromosome X r cessive Syndrome de Barth : ... Author: g-psl ...

Title: No Slide Title Author: TIMOTHY A. DENTON Last modified by: Tim Denton Created Date: 7/29/1998 9:17:54 PM Document presentation format: 35mm Slides

Uterus, testis, pituitary, ovary, epididymis, and adrenal gland. ER-b (Kuiper et al. 1996) brain, kidney, prostrate, ovary, lung, bladder, intestine, and epididymis. ...

Approaches to First-In-Man and Beyond: Early Evidence of Target ... Time to First Emesis or Rescue. Part II: Novel Clinical Trial Designs. 24. Response. Dose ...

Title: Progress o da Diabetes Tipo II Author: Maputo Last modified by: Henrique Mendes Cabral Created Date: 2/24/2003 12:55:22 PM Document presentation format

Their hydrophobic and oleophobic properties make them ideal surfactants (water ... Ovarian tubular hyperplasia. PFOS. Liver adenomas. Thyroid adenomas/carcinomas ...

Hepatic inducing agents. Induction of UDPGT and metabolism of T4 ... Hepatic enlargement and hyperplasia. Strong ... Low hepatic levels in human and g-pig ...

Men 102 cm ( 40 in) Women 88 cm ( 35 in) Triglycerides ... Expressed throughout vasculature; limits adhesion molecule expression,tissue factor production ...

Metabolic Complications of HIV Dr Lou Haenel, Jr Endocrinology 12/10 Terminology Lipodystrophy Lipoatrophy Lipohypertrophy HIV HAART (Highly Active Anti-Retroviral ...

Potential Causes of the Metabolic Syndrome & Insulin Resistance ... Defect in fat oxidation may be a precursor to obesity and the metabolic syndrome. ...

Linoleic acid nitration results can be found in: O'Donnell et al. Chem Res Tox 12: 83-92, 1999. ... Synthesis of Nitrated Linoleic Acid. PNAS 101:11577-11582, 2004 ...

Ubiquitously expressed - especially in the liver, small ... ENDOGENOUS. CM. TG rich. VLDL. TG rich. IDL. LDL. Cholesterol rich. LIVER. CMR. TG rich. LIVER ...

T47-D (ERa endogenous) ERE3-TATA-luc. ER calux (Legler J, 1999) ... HEK293 (ERa or ERb) ERE3-TATA-Luc. ( Schreurs R, 2002). CHO (ERa or ERb) RO-Luc. ...

Presencia de receptores y sus ligandos en diversos organismos indica la ... del apetito. Aumento de peso. a expensas de masa corporal. Teor a. Pr ctica ...

Risk Perception, Risk Assessment and the Role of ... Dehydroepiandrosterone acetate. Halothane. 2,4-D. 2,4,5,-T. MCPA. Dimethrin. Lactofen. Formesafen ...

A considerable amount of data confirming the influence of genes on human ... 90 row-ers were evaluated by PM 3 Rower Ergometer and Meta-Max 3B Gas Analyzer. ...

When we do liposuction, we remove subcutaneous fat not visceral fat. ... No eat High Glycemic index foods. Low carbohydrate diet. Ornish Diet ...

MITOCHONDRIAL BIOGENESIS AND REDOX REGULATION Claude A. Piantadosi, MD Professor of Medicine and Pathology Duke University Medical Center Durham, N.C. USA

The Role of Biopathways in Drug Repositioning and Determining Side Effects

When we do liposuction, we remove subcutaneous fat not visceral fat. ... Sugar Busters. Sugar and Insulin make you fat. Decrease sugar content in food. Zone Diet ...

Congestive heart failure. 1IGJ. A Reverse Engineering Approach to ... and tolcapone are used as COMT inhibitors in Parkinson's disease treatment. Hypothesis: ...

Cholesterol Synthesis, Endocytosis and Hyperlipidemia June 7, 2004 (153C) Peter A. Edwards (Department of Biological Chemistry) Hyperlipidemia Total LDL HDL ...

Journal Club Adam G Tabak, Markus Jokela, Tasnime N Akbaraly, Eric J Brunner, Mika Kivimaki, Daniel R Witte Trajectories of glycaemia, insulin sensitivity, and ...

Trends in Drug Discovery and Development Unmet medical needs Choosing appropriate disease and therapeutic area Creating a suitable research environment and ...

Phar 722 Pharmacy Practice III Obesity and Weight Control Spring 2006 Study Guide for the Material on Obesity 1. For obesity, know: a. causes; b. reasons for the ...

CV risk factors and Lifestyle Modification among South Asians A call to action Dr. Sonia Anand MD, PhD Associate Professor of Medicine McMaster University

oxidize. cleave. CoA. Acyl-CoA. dehydrogenase. Enoyl-CoA. hydratase. 3 ... Oxidize very long chain fatty acids ( 20c) About 10% of all b-ox occurs in peroxisome ...

... (Common increases in Tf cassettes): - Myosin regulation - Mitochondrial genes ... DIFFERENCES (Oppositely directed Tf cassettes): - PDH (synthesis of components) ...

Concertar a un grupo de investigadores con experiencias cient ficas ... suggest that copper induced PrP localization in specific cellular compartments. ...

Entrenamiento en la Investigaci n Biom dica dentro del marco de los Programas de ... For more information plese see article by Chac n et al. On pages 953-961 ...

Drugs for Metabolic Disorders

Incidence of Urinary Bladder Proliferative Lesions in Male Rats ... No urinary bladder cytotoxic, proliferative, or inflammatory changes in monkeys after 1 year ...

Universidade Federal da Bahia Faculdade de Direito Mestrado Profissional em Seguran a P blica, Justi a e Cidadania Justi a Restaurativa Aplicada ao Juizado ...

Using visualization to find relationships in chemogenomic data ... Toxicology. CAS. ISIS. ABase. CodeLink. Multidisciplinary Drug Compound Candidate Project Team ...

Hazard x exposure (dose and time) The chance (probability) that ... brocolli. brussel sprouts. cabbage. carrots. cauliflower. celery. cinnamon. cloves. cocoa ...

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